ognizant Communication Corporation

Analgesia is an international journal published four times a year that provides for the rapid review and publication in English of original research reports and reviews involving rigorous ethical experimental studies on the basic mechanisms and therapeutics of pain relief. Preclinical studies will be considered that are directed toward any aspect of pain pathways (e.g., anatomical, biochemical, molecular, pharmacological, or physiological) and their identification; that involve the study of neurotransmitters or modulators; or that investigate some aspect of known or experimental analgesic/antinociceptive compounds (including side effects). Clinical studies will be considered that help elucidate the mechanism of action of known analgesic drugs or that report on the use of combinations. Novel methodological, statistical, theoretical, or mathematical approaches will also be considered.

Submission of Manuscripts: Manuscripts must be in English, typewritten and double-spaced on 8 1/2 x 11- inch paper with 1-inch margins printed on one side only. The original should not be stapled. Submit four complete copies of the manuscripts to:

Cover Letter: A cover letter must accompany the submission with the following information: (1) Names, addresses, and Fax and telephone numbers of at least four potential, qualified reviewers. (2) A statement that neither the manuscript nor the data contained therein have been published previously nor are under consideration for publication elsewhere. (3) A statement that all authors approve of submission and that persons cited for unpublished work or personal communication have approved such citation. (4) A statement, where appropriate, that the authors' employers or study sponsors have approved submission.

Manuscript Preparation: Arrange the manuscript as follows, with each section beginning on a separate page: (1) Title page, (2) Running title, Grant support, or other footnotes, (3) Abstract and Keywords, (4) Introduction, (5) Methods, (6) Results, (7) Discussion, (8) Acknowledgements, (9) References, (10) Figure legends, (11) Tables. Place the author's name in the upper right-hand corner of each page. Number each page. It aids the review process if the lines on each page are numbered.

(1) Title page: Title: Provide complete title, including species where appropriate. Authors: Provide full name of all authors and the laboratory(s) in which the work was done. The authors' present affiliations, where different, can be included in a footnote.
Correspondence: List complete address of corresponding author, including telephone and Fax numbers and E-mail if available.

(2) Second Page: Include a descriptive running title limited to 45 spaces, including punctuation. Grant support, present addresses, previous preliminary reports of the data, etc., should be listed as footnotes.

(3) Abstract and Keywords: Limit to 250 words and organize according to the following headings: Background, Purpose, Methods, Results, Conclusions. Do not use references or footnotes in the Abstract. Keywords for indexing should be provided on the same page as the Abstract.

(4) Introduction, Methods, Results, Discussion: Follow standard practices according to the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals" developed by the International Committee of Medical Journal editors and published in N. Engl. J. Med. 324: 424-428, 1991. Specific instructions include the following:

• Generic names should be used throughout. Trade names may be mentioned in parentheses in the first text reference, but not in title, figure legends, or tables. Manuscripts will not be published in which the chemical names of compounds or their structures are not given.
• The form of drug used to calculate dose (e.g., base or salt) must be indicated. When comparisons of a potency are made, the doses must be converted to a comparable unit (e.g., mumol).
• Define abbreviations the first time they appear in the text. Abbreviations not requiring specific definitions include °C, g, IV, IP, SC, IM, PO, mol, M, h, min, s, SD, SE, ANOVA, ED₅₀, and standard units such as m (milli-), mu (micro-), p (pico-), etc.
• Statistical analyses must be explicitly and clearly stated.

(6) Figures: Submit four complete sets of high-quality glossy photographs or laser-printer quality figures on glossy or high-quality paper stock. Attach a photocopy of each figure to each copy of the manuscript. In the case of multiple sections of a single figure, indicate the required (or suggested) layout. Identify each figure with the first author's last name, figure number, and an arrow indicating the top on a self-adhesive label affixed to the back of each figure.

Computer Disk: To speed publications and ensure accuracy, authors are required to submit a computer disk that contains the final version of their paper along with the final manuscript to the editorial office. Please observe the following criteria: 1. Specify what software was used, including which release(e.g., Microsoft Word 97). 2. Specify what computer was used (PC or Macintosh). 3. Include both document file and ASCII (text) file on the disk. 4. The file should be single spaced and should use wrap around end of line features (i.e., no return at the end of the line). All textual elements should begin flush left, no paragraph indents. Place two returns after every element, such as title, heading, paragraphs, figure and table callouts, etc. 5. Keep back-up disk for reference and safety. Note: Please ensure that the final hard copy and electronic file copy match.

Rapid Communications: Papers representing particularly concise and definitive studies will be considered as Rapid Communications upon the request of the author(s). If accepted, the paper will be scheduled for publication in the next available issue of the Journal. Manuscripts must be limited to the following conditions to be considered for this section: Abstract: maximum of 100 words. Length of paper: maximum of 750 words (including Abstract, Figure legends, and References). Figures and Tables: maximum of 2 total.

Page Proofs: Page proofs must be returned within 48 hours of receipt. At this stage of production, major corrections may be made only with the approval of the Editors. The cost for any such corrections will be borne by the author.

Copyright Agreement: If accepted for publication, copyright in the article, including the right to reproduce the article in all forms and media, shall be assigned exclusively to Cognizant Communication Corporation. Reasonable requests for permission to reproduce contributions will not be denied. It will be necessary for all authors to sign an assignment of copyright form upon provisional acceptance of the manuscript (except on work done by U.S. Federal Government employees).

Disclaimer: Although every effort is made by the publisher and editorial board to see that no inaccurate or misleading data, opinion, or statement appears in this journal, they wish to make it clear that the data and opinions appearing in the articles and advertisements herein are the sole responsibility of the contributor or advertiser concerned. Accordingly, the publisher, editors, editorial board, and their respective employees, officers, and agents accept no responsibility or liability whatsoever for the consequences of any such inaccurate or misleading data, opinions, or statements.