ognizant Communication Corporation

Reviews in Analgesia (formerly Analgesia) is an international journal that publishes in English original reviews by experts on topics related to the basic mechanisms and therapeutics of pain relief. Reviews are invited that focus on pain mechanisms, endogenous mediators of pain, mechanisms of analgesia, and the synthesis, testing, or mechanism of action study of known or experimental analgesic compounds-including nonanalgesic and side effect endpoints and abuse liability. In addition, reviews of clinical studies or practice are invited that help elucidate the mechanism of action of known analgesic drugs, or that report on the use of experimental compounds or combinations. Reviews on new or standard methodological approaches, statistical analyses, and theoretical or mathematical treatments are also invited.

Submission of Manuscripts: Submit two unstapled, paginated hard copies, in English, typewritten and double-spaced with 1-inch margins, printed on one side only of 8 1/2 x 11-inch paper. An electronic version (MSWord.doc) of the final accepted manuscript must also be submitted (see Final Accepted Manuscript below) to: Robert B. Raffa, Ph.D., Editor-in-Chief, Reviews in Analgesia, Temple University School of Pharmacy, 3307 N. Broad Street, Philadelphia, PA 19140. Tel: 215-707-4976; Fax: 215-707-5228; E-mail: robert.raffa@temple.edu

Cover Letter: A cover letter accompanying the submission should contain the following information: (1) Names, addresses, and Fax and telephone numbers of at least four qualified reviewers. (2) A statement that the work is original. (3) A statement that all authors approve of the submission and that persons cited for unpublished work or personal communication have approved such citation. (4) A statement, where required, that the authors' employers or study sponsors have approved submission.

Manuscript Preparation: The average length of reviews should be about 20-30 typewritten pages, but can be shorter or much longer (use Times or similar font and 12-point type). Place first author's name in the upper right-hand corner of each page. The organization of the review is optional, but it must have an Abstract (of about 150 words) and Key Words, Introduction, and Summary. Arrange the manuscript as follows: (1) Title page, (2) Short title, Abbreviations, any title page footnotes, (3) Abstract and key words, (4) Introduction and main text, (5) Acknowledgments and Grant support, (6) References, (7) Tables, (8) Figure legends, (9) Figures.

Title Page: Provide complete title, including species where appropriate. Provide full names of all authors and affiliations when the work was prepared. An author's present address if different, should be included as a footnote. List complete present addresses of all authors, include telephone and fax numbers, and e-mail address. Clearly identify the corresponding author.

Short Title, Abbreviations, Footnotes: Provide a descriptive short title limited to 45 spaces. Provide a list of abbreviations used in the manuscript (note that each abbreviation should be defined with the abbreviation in parentheses the first time it is used in the manuscript). Provide title page footnotes such as prior preliminary reports of the data or an author's present address.

Abstract and Key Words: Provide a short (about 150 words) paragraph summarizing the main points of the manuscript (do not use references in the abstract). Provide 4-6 key words for indexing.

Introduction and Main Text: Introduction should be the initial heading, but subsequent headings and manuscript organization are the option of the author. Main and subheadings should be clearly identified. Follow standard practices such as the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals" developed by the International Committee of Medical Journal editors and published in New England Journal of Medicine, 324:424-428, 1991. Specific instructions include the following:

• Generic names should be used throughout. Trade names may be mentioned in parentheses in the first text reference, but not in the title, figure legends, or tables. Manuscripts will not be published in which the chemical names of compounds or their structures are not given.
• The name and form of drug used to calculate dose (e.g., base or salt) must be indicated and when comparisons of potency are made, the doses must be converted to a comparable unit (e.g., mmol).
• Statistical analyses must be explicitly and clearly stated.

References: References should be prepared using the Numbered/Alphabetical style. References should be cited in the text with numbers in parentheses. In the list of references, they should be numbered and arranged alphabetically by author, according to the following samples (note: provide all authors names; do not use et al. in the reference list):

• Journal articles: Raffa, R. B.; Wild, K. D.; Mosberg, H. I.; Porreca, F. Thermodynamic parameters for [D-Pen^2,5]enkephalin a delta-opioid receptors in the mouse isolated vas deferens. Eur. J. Pharmacol. 224:231-238; 1993.
• Books: Tallarida, R. J.; Murray, R. B. Manual of pharmacologic calculations with computer programs. New York: Springer-Verlag; 1987.
• Book Chapters: Rothman, R. B. Antiopioid peptides in morphine tolerance and dependence. In: Hammer, R. P., ed. The neurobiology of opiates. Boca Raton, FL: CRC Press; 1992:147-164.

Figure Legends: Provide figure legends on a separate page. Provide a legend for each figure. The legend should be complete (i.e., the reader should be able to understand the information presented and its interpretation without reference to the text).

Figures: Figures should be cited in sequence in the text. All figures must be cited. Avoid extremely wide or long figures. Labeling should be large enough to be legible after reduction to fit page dimensions. Submit two sets of high-quality glossy photographs or laser printer quality figures on high-quality paper stock. Include a photocopy of each figure as a separate numbered page at the end of the manuscript. Identify each figure with the fist author's last name, figure number, and an arrow indicating the top on a self-adhesive label affixed to the back of each figure.

Final Accepted Manuscript: Authors whose manuscript is accepted for publication must submit the final version of the manuscript in digital format on disk, as well as by hard copy (two complete final copies), to the Editor-in-Chief. Please ensure that the hard copy and electronic file match exactly.

Page Proofs and Offprints: Page proofs will be sent to the designated corresponding author prior to publication. Minor changes only are allowed at this stage. A form for ordering offprints and copies of the journal issue in which the article appears will accompany the page proofs.

Although every effort is made by the publisher and editorial board to see that no inaccurate or misleading data, opinion, or statement appears in this journal, they wish to make it clear that the data and opinions appearing in the articles and advertisements herein are the sole responsibility of the contributor or advertiser concerned. Accordingly, the publisher, the editorial board, editors, and their respective employees, officers, and agents accept no responsibility or liability whatsoever for the consequences of any such inaccurate or misleading data, opinion, or statement.