ognizant Communication Corporation

CELL TRANSPLANTATION
The Regenerative Medicine Journal

TABLES OF CONTENTS
VOLUME 13, 2004

VOLUME 13, NUMBERS 7/8, 2004

Commentary

Healing a Broken Heart With Stem Cells
David M. Stern, David C. Hess, and Cesar V. Borlongan

Original Contributions

Human Umbilical Cord Blood Mononuclear Cells for the Treatment of Acute Myocardial Infarction
Robert J. Henning, Hamdi Abu-Ali, John U. Balis, Michael B. Morgan, Alison E. Willing, and Paul R. Sanberg

G-CSF Promotes Bone Marrow Cells to Migrate Into Infarcted Mice Heart, and Differentiate Into Cardiomyocytes
Shinya Fukuhara, Shinji Tomita, Takeshi Nakatani, Yoshinori Ohtsu, Michiko Ishida, Chikao Yutani, and Soichiro Kitamura

Evaluation of Surgical Techniques for Neuronal Cell Transplantation Used in Patients With Stroke
Douglas Kondziolka, Gary K. Steinberg, Sean B. Cullen, and Michael McGrogan

Formation and Structure of Transplantable Tissue Constructs Generated in Simulated Microgravity From Sertoli Cells and Neuron Precursors
Don F. Cameron, J. J. Hushen, L. Colina, J. Mallery, A. Willing, P. R. Sanberg, and Samuel Saporta

The Potential of Bone Marrow Stem Cells to Correct Liver Dysfunction in a Mouse Model of Wilson's Disease
Katrina J. Allen, Daphne M. Y. Cheah, Xiao Ling Lee, Nicole E. Pettigrew-Buck, Jim Vadolas, Julian F. B. Mercer, Panayiotis A. Ioannou, and Robert Williamson

A Simple and Effective Method to Improve Intrasplenic Rat Hepatocyte Transplantation
Valeria Sigot, María G. Mediavilla, Graciela Furno, Joaquín V. Rodríguez, and Edgardo E. Guibert

Cytotoxic Immune Response to a Xenogeneic Bioartificial Liver
Scott L. Nyberg, Bruce Amiot, Joseph Hardin, Edwina Baskin-Bey, and Jeffrey L. Platt

cDNA Microarray Analysis in Hepatocyte Differentiation in Huh 7 Cells
Yo-ichi Yamashita, Mitsuo Shimada, Norifumi Harimoto, Shinji Tanaka, Ken Shirabe, Hiroyuki Ijima, Kohji Nakazawa, Junji Fukuda, Kazumori Funatsu, and Yoshihiko Maehara

Effect of Inspired Oxygen on Portal and Hepatic Oxygenation: Effective Arterialization of Portal Blood by Hyperoxia
Stephen J. Hughes, Wenxuan Yang, Maciej Juszczak, Gareth L. Jones, Stephen H. Powis, Alexander M. Seifalian, and Martin Press

Bioreactor Microcarrier Cell Culture System (Bio-MCCS) for Large-Scale Production of Autologous Melanocytes
Jin Yu Liu, Jürg Hafner, Galya Dragieva, and Günter Burg

A Comparison Between Real-Time Quantitative PCR and DNA Hybridization for Quantitation of Male DNA Following Myoblast Transplantation
Erika Bosio, Tracey F. Lee-Pullen, Clayton T. Fragall, Manfred W. Beilharz, Alayne L. Bennett, Miranda D. Grounds, Stuart I. Hodgetts, and Leanne M. Sammels

Maintenance of Functional Human Cancellous Bone and Human Hematopoiesis in NOD/SCID Mice
Frédérique Hubin, Chantal Humblet, Zakia Belaid, Roland Greimers, Jacques Boniver, Albert Thiry, and Marie-Paule Defresne

Lack of Cytomegalovirus Transmission After Pancreatic Islet Transplantation
Neal R. Barshes, Timothy C. Lee, F. Charles Brunicardi, Amy Mote, A. Paige Schock, Rodolfo Alejandro, Camillo Ricordi, and John A. Goss

Brief Communication

Dose-Dependent Neurochemical and Functional Protection Afforded by Encapsulated CNTF-Producing Cells
Dwaine F. Emerich

Volume 13 Subject and Author Index



VOLUME 13, NUMBER 6, 2004

REVIEW

Methods of Human Islet Culture for Transplantation
T. B. Murdoch, D. McGhee-Wilson, A. M. J. Shapiro, and J. R. T. Lakey

ORIGINAL CONTRIBUTIONS

Comparison of Tolerated and Rejected Islet Grafts: A Gene Expression Study
Tobias Berg, Tao Wu, Brett Levay-Young, Neal Heuss, Yisheng Pan, Nicole Kirchhof, David E. R. Sutherland, Bernhard J. Hering, and Zhiguang Guo

Individual Human Serum Differs in the Amount of Antibodies With Affinity for Pig Fetal Ventral Mesencephalic Cells and the Ability to Lyse These Cells by Complement Activation
Jan Koopmans, Aalzen de Haan, Elinda Bruin, Ieneke van der Gun, Henk van Dijk, Jan Rozing, Lou de Leij, and Michiel Staal

Comparison of Intramyocardial and Intravenous Routes of Delivering Bone Marrow Cells for the Treatment of Ischemic Heart Disease: An Experimental Study
Masanori Hayashi, Tao-Sheng Li, Hiroshi Ito, Akihito Mikamo, and Kimikazu Hamano

Viability of Allogeneic Bone Marrow Stromal Cells Following Local Delivery Into Patella Tendon in Rabbit Model
Hong Wei Ouyang, James C. H. Goh, and Eng Hin Lee

Reevaluation of Bone Marrow-Derived Cells as a Source for Hepatocyte Regeneration
Tobias Cantz, Amar Deep Sharma, Andrea Jochheim-Richter, Lubomir Arseniev, Christoph Klein, Michael P. Manns, and Michael Ott

Hypothermia Inhibits Fas-Mediated Apoptosis of Primary Mouse Hepatocytes in Culture
Tao Fu, Andres T. Blei, Noriaki Takamura, Tesu Lin, Danqing Guo, Honglin Li, Maurice R. O'Gorman, and Humberto E. Soriano

Optimization of Conditions for Clinical Human Hepatocyte Infusion
Robert A Fisher, Dawen Bu, Melissa Thompson, Luke Wolfe, and Joseph K. Ritter

Transplantation of Cultured Salivary Gland Cells Into an Atrophic Salivary Gland
T. Sugito, H. Kagami, K. Hata, H. Nishiguchi, and M. Ueda

Allogeneic Versus Xenogeneic Immune Reaction to Bioengineered Skin Grafts
Gulsun Erdag and Jeffrey R. Morgan

Improved Histological Evaluation of Vascularity Around an Immunoisolation Device by Correlating Number of Vascular Profiles to Glucose Exchange
Anne Sörenby, Ehab Rafael, Annika Tibell, and Annika Wernerson

BOOK REVIEW

Stem Cell Transplantation for Hematologic Malignancies (Robert J. Soiffer, editor)
Nagwa S. El-Badri, Zubair Kazi, and Paul R. Sanberg



VOLUME 13, NUMBER 5, 2004

Commentary

The Convergence of Cell Transplantation and Nanoengineering
Dwaine F. Emerich

Original Contributions

Variation in Human Islet Viability Based on Different Membrane Integrity Stains
M. J. Barnett, D. McGhee-Wilson, A. M. J. Shapiro, and J. R. T. Lakey

Retrovirally Transferred Genes Inhibit Apoptosis in an Insulin-Secreting Cell Line: Implications for Islet Transplantation
Elizabeth S. Fenjves, M. Sofia Ochoa, Carlota Gay-Rabinstein, Camillo Ricordi, and Michael A. Curran

The Use of Multiparametric Monitoring During Islet Cell Isolation and Culture: A Potential Tool for In-Process Corrections of Critical Physiological Factors
Chris Fraker, Jorge Montelongo, Joel Szust, Aisha Khan, and Camillo Ricordi

The Contribution of Chemokines and Chemokine Receptors to the Rejection of Fetal Proislet Allografts
Michelle. F. Solomon, William A. Kuziel, and Charmaine J. Simeonovic

Factors Influencing Functional Survival of Microencapsulated Islet Grafts
Paul de Vos, Bart J. de Haan, Aalzen de Haan, Jacoba van Zanten, and Marijke M. Faas

Comparison of Fetal Porcine Aggregates of Purified b-Cells Versus Islet-Like Cell Clusters as a Treatment of Diabetes
Jian Tu, Pauline Khoury, Lindy Williams, and Bernard E. Tuch

Studies on the Differentiation of Dopaminergic Traits in Human Neural Progenitor Cells In Vitro and In Vivo
Ming Yang, Angela E. Donaldson, Cheryl E. Marshall, James Shen, and Lorraine Iacovitti

Photofabricated Gelatin-Based Nerve Conduits: Nerve Tissue Regeneration Potentials
Eduardo Gámez, Yoshinobu Goto, Kengo Nagata, Toru Iwaki, Tomio Sasaki, and Takehisa Matsuda

Efficient Early and Sustained Transduction of Human Fetal Mesencephalon Using Adeno-Associated Virus Type 2 Vectors
L. Tenenbaum, M. Peschanski, C. Melas, F. Rodesh, E. Lehtonen, A. Stathopoulos, T. Velu, J. Brotchi, and M. Levivier

In Vivo Evaluation of Pharmacologically Active Microcarriers Releasing Nerve Growth Factor and Conveying PC12 Cells
V. M. Tatard, M. C. Venier-Julienne, J. P. Benoit, P. Menei, and C. N. Montero-Menei

The Transfer of Ocular Cells Using Collagen
Chi-Kong Yeung, Sylvia Wai-Yee Chiang, Kwok-Ping Chan, Dennis Shun-Chiu Lam, and Chi-Pui Pang

Autologous Bone Marrow Stromal Cell Transplantation for Repair of Full-Thickness Articular Cartilage Defects in Human Patellae: Two Case Reports
Shigeyuki Wakitani, Tomoki Mitsuoka, Norimasa Nakamura, Yukiyoshi Toritsuka, Yukio Nakamura, and Shuji Horibe

Book Review

Hematopoietic Stem Cell Protocol (Christopher A. Klug, Craig T. Jordan)
Guoqing Liu, Paul R. Sanberg, Cyndy Davis Sanberg, and Zubair Kazi



VOLUME 13, NUMBER 4, 2004

Japanese Society for Regenerative Medicine: Introduction
Noriaki Tanaka

Embryonic Stem Cells Form Articular Cartilage, not Teratomas, in Osteochondral Defects of Rat Joints
Shigeyuki Wakitani, Hideyuki Aoki, Yasuji Harada, Masato Sonobe, Yusuke Morita, Ying Mu, Naohide Tomita, Yukio Nakamura, Satoshi Takeda, Takeshi K. Watanabe, and Akira Tanigami

Effects of Osteogenic Induction on Mesenchymal Cells From Fetal and Maternal Parts of Human Placenta
Kenji Takahashi, Koichi Igura, Xiaohong Zhang, Ayako Mitsuru, and Tsuneo A. Takahashi

Translational Research for Injectable Tissue-Engineered Bone Regeneration Using Mesenchymal Stem Cells and Platelet-Rich Plasma: From Basic Research to Clinical Case Study
Yoichi Yamada, Minoru Ueda, Hideharu Hibi, and Tetsuro Nagasaka

Osteogenic Potential of Cultured Bone/Ceramic Construct: Comparison With Marrow Mesenchymal Cell/Ceramic Composite
Jin Iida, Takafumi Yoshikawa, Manabu Akahane, Hajime Ohgushi, Yoshiko Dohi, Yoshinori Takakura, and Akitaka Nonomura

Bone Tissue Engineering Using Novel Interconnected Porous Hydroxyapatite Ceramics Combined With Marrow Mesenchymal Cells: Quantitative and Three-Dimensional Image Analysis
Masataka Nishikawa, Akira Myoui, Hajime Ohgushi, Masako Ikeuchi, Noriyuki Tamai, and Hideki Yoshikawa

Enhancement of In Vitro Osteoblastic Potential After Selective Sorting of Osteoblasts With High Alkaline Phosphatase Activity From Human Osteoblast-Like Cells
Noriko Kotobuki, Motohiro Hirose, Hiroyuki Funaoka, and Hajime Ohgushi

Propagation of Adult Rat Bone Marrow-Derived Hepatocyte-Like Cells by Serial Passages In Vitro
Masahiro Miyazaki, Takuro Masaka, Ichiro Akiyama, Emiko Nakashima, Masakiyo Sakaguchi, and Nam-ho Huh

Functional Activity of Human Hepatoma Cells Transfected With Adenovirus-Mediated Hepatocyte Nuclear Factor (HNF)-4 Gene
Takafumi Naiki, Masahito Nagaki, Yoshihiro Shidoji, Hisanori Kojima, and Hisataka Moriwaki

Transplanted Mesenchymal Stem Cells Are Effective for Skin Regeneration in Acute Cutaneous Wounds
Hiroko Satoh, Kazuo Kishi, Takara Tanaka, Yoshiaki Kubota, Tatsuo Nakajima, Yoshikiyo Akasaka, and Toshiharu Ishii

Transplantation of Nonvascularized Kidney Tissue Fragments Into the Rat Liver With the Aim of Preserving Renal Function
Shin Enosawa, Nanae Takahashi, Hiroshi Amemiya, and Yoshihiro Motomiya

Vigorous Neuronal Differentiation of Amplified and Grafted Basic Fibroblast Growth Factor-Responsive Neurospheres Derived From Neuroepithelial Stem Cells
Motoyuki Yamada, Koichi Uchida, Takuro Hayashi, Yutaka Mine, Yasuo Toda, and Takeshi Kawase

Therapeutic Angiogenesis by Autologous Bone Marrow Cell Implantation for Refractory Chronic Peripheral Arterial Disease Using Assessment of Neovascularization by 99mTc-Tetrofosmin (TF) Perfusion Scintigraphy
Masaaki Miyamoto, Masahiro Yasutake, Hitoshi Takano, Hiromichi Takagi, Gen Takagi, Hiroshi Mizuno, Shinichiro Kumita, and Teruo Takano

In Vivo Tissue-Engineered Small-Caliber Arterial Graft Prosthesis Consisting of Autologous Tissue (Biotube)
Yasuhide Nakayama, Hatsue Ishibashi-Ueda, and Keiichi Takamizawa

Development of a Hydroxyapatite/Collagen Nanocomposite as a Medical Device
Soichiro Itoh, Masanori Kikuchi, Yoshihisa Koyama, Kazuo Takakuda, Kenichi Shinomiya, and Junzo Tanaka

Collagen Vitrigel: A Novel Scaffold That Can Facilitate a Three-Dimensional Culture for Reconstructing Organoids
Toshiaki Takezawa, Katsuyuki Ozaki, Aya Nitani, Chiyuki Takabayashi, and Tadashi Shimo-Oka

Erratum



VOLUME 13, NUMBER 3, 2004

ORIGINAL CONTRIBUTIONS

Differentiation of Human and Mouse Embryonic Stem Cells Along a Hepatocyte Lineage
Hitoshi Shirahashi, Jian Wu, Naoki Yamamoto, Andreea Catana, Henning Wege, Brook Wager, Kiwamu Okita, and Mark A. Zern

Comparison of Bioenergetic Activity of Primary Porcine Hepatocytes Cultured in Four Different Media
Konstantinos J. Dabos, Leonard J. Nelson, Chandralal H. Hewage, John A. Parkinson, A. Forbes Howie, Ian H. Sadler, Peter C. Hayes, and John N. Plevris

Engraftment Measurement in Human Liver Tissue After Liver Cell Transplantation by Short Tandem Repeats Analysis
Valeria R. Mas, Daniel G. Maluf, Melissa Thompson, Andrea Ferreira-Gonzalez, and Robert A. Fisher

Polyvinyl Pyrrolidone: A Novel Cryoprotectant in Islet Cell Cryopreservation
Hesham M. El-Shewy, William F. Kendall, Jr., Marcus Darrabie, Bradley H. Collins, and Emmanuel C. Opara

The Effects of Transforming Growth Factor-\GK\b2 on Dopaminergic Graft Survival
Shannon L. Macauley, Alexander D. Horsch, Marinus Oterdoom, Ming  H. Zheng, and Gregory R. Stewart

BRIEF COMMUNICATION

Neuroprotective Effects of Encapsulated CNTF-Producing Cells in a Rodent Model of Huntington's Disease Are Dependent on the Proximity of the Implant to the Lesioned Striatum
Dwaine F. Emerich and Shelley R. Winn

NEUROSCIENCE SPECIAL SECTION

Emerging Strategies in Neural Transplantation and Repair: A Special Section Based on the 10th ASNTR Meeting
Timothy J. Collier

Liposomal Formulations of Tacrolimus and Rapamycin Increase Graft Survival and Fiber Outgrowth of Dopaminergic Grafts
Aylin Y. Alemdar, Damaso Sadi, Vivian C. McAlister, and Ivar Mendez

Reassessment of Caspase Inhibition to Augment Grafted Dopamine Neuron Survival
Deanna M. Marchionini, Timothy J. Collier, Mark R. Pitzer, and Caryl E. Sortwell

Intracerebral Xenotransplantation of GFP Mouse Bone Marrow Stromal Cells in Intact and Stroke Rat Brain: Graft Survival and Immunologic Response
H. Irons, J. G. Lind, C. G. Wakade, G. Yu, M. Hadman, J. Carroll, D. C. Hess, and C. V. Borlongan

Comparison of Embryonic Stem Cell-Derived Dopamine Neuron Grafts and Fetal Ventral Mesencephalic Tissue Grafts: Morphology and Function
David M. Yurek and Anita Fletcher-Turner

REVIEW

Graft-Induced Plasticity in the Mammalian Host CNS
Jitka Ourednik and Václav Ourednik

COMMENTARY

A Perspective on Transplantation Therapy and Stem Cells for Parkinson's Disease
William J. Freed



VOLUME 13, NUMBER 2, 2004

ORIGINAL CONTRIBUTIONS

Clonal Population of Adult Stem Cells: Life Span and Differentiation Potential
Mitchel Seruya, Anup Shah, Dawn Pedrotty, Tracey du Laney, Ryan Melgiri, J. Andrew McKee, Henry E. Young, and Laura E. Niklason

Transplantation of Adipose Tissue-Derived Stromal Cells Increases Mass and Functional Capacity of Damaged Skeletal Muscle
Francis Bacou, Ramzi Boubaker el Andalousi, Paul-André Daussin, Jean-Paul Micallef, Jonathan M. Levin, Michel Chammas, Louis Casteilla, Yves Reyne, and Jean Nouguès

Intraspinal Transplantation of CD34+ Human Umbilical Cord Blood Cells After Spinal Cord Hemisection Injury Improves Functional Recovery in Adult Rats
Zong Mao Zhao, Hong Jun Li, Hai Ying Liu, Shi Hong Lu, Ren Chi Yang, Qing Jun Zhang, and Zhong Chao Han

Transplanted hNT Cells ("LBS Neurons") in a Rat Model of Huntington's Disease: Good Survival, Incomplete Differentiation, and Limited Functional Recovery
Rosemary A. Fricker-Gates, Janice A. Muir, and Stephen B. Dunnett

Natural Antibodies Prevent In Vivo Transmission of Porcine Islet-Derived Endogenous Retrovirus to Human Cells
Brice W. McKane, Sabarinathan Ramachandran, Xiao-Chun Xu, Barbara J. Olack, William C. Chapman, and T. Mohanakumar

Polyphenol, an Extract of Green Tea, Increases Culture Recovery Rates of Isolated Islets From Nonhuman Primate Pancreata and Marginal Grade Human Pancreata
Guangming Zhang, Shinichi Matsumoto, Suong-Hyu Hyon, Sabrina A. Qualley, Lisa Upshaw, D. Michael Strong, and Jo-Anna Reems

Endogenous Pancreatic Enzyme Activity Levels Show no Significant Effect on Human Islet Isolation Yield
Natisha L. Rose, Monica M. Palcic, A. M. James Shapiro, and Jonathan R. T. Lakey

Fate of a Chimeric Joint Construct in an Ectopic Site in SCID Mice
Scott Warden, David J. Zaleske, and Julie Glowacki

Tissue-Engineered Grafts Matured in the Right Ventricular Outflow Tract
Tsukasa Ozawa, Donald A. G. Mickle, Richard D. Weisel, Keiji Matsubayashi, Takeshiro Fujii, Paul W. M. Fedak, Nobuya Koyama, Yoshito Ikada, and Ren-Ke Li

Assessment of Different Transfection Parameters in Efficiency Optimization
A. T. L. Young, R. B. Moore, A. G. Murray, J. C. Mullen, and J. R. T. Lakey

Long-Term Function of Cryopreserved Rat Hepatocytes in a Coculture System
Keishi Sugimachi, Meindert N. Sosef, John M. Baust, Alex Fowler, Ronald G. Tompkins, and Mehmet Toner



VOLUME 13, NUMBER 1, 2004

REVIEW

Transgenic Sertoli Cells as a Vehicle for Gene Therapy
Jannette M. Dufour, Paul Gores, Richelle Hemendinger, Dwaine F. Emerich, and Craig R. Halberstadt

ORIGINAL CONTRIBUTIONS

Autotransplantation of Unmanipulated Bone Marrow Into Scarred Myocardium Is Safe and Enhances Cardiac Function in Humans
Manuel Galiñanes, Mahmoud Loubani, Joan Davies, Derek Chin, John Pasi, and Peter R. Bell

Development and Transplantation of a Mineralized Matrix Formed by Osteoblasts In Vitro for Bone Regeneration
Yin Xiao, Helen Haase, William G. Young, and P. Mark Bartold

The Origin of Biliary Ductular Cells That Appear in the Spleen After Transplantation of Hepatocytes
Kenji Fukuda, Ayako Sugihara, Keiji Nakasho, Tohru Tsujimura, Naoko Yamada, Atsuhito Okaya, Masafumi Sakagami, and Nobuyuki Terada

Cryopreservation of Alginate-Encapsulated Recombinant Cells for Antiangiogenic Therapy
V. Stensvaag, T. Furmanek, K. Lønning, A. J. A. Terzis, R. Bjerkvig, and T. Visted

Y Chromosome Detection of Three-Dimensionissue-Engineered Skeletal Muscle Constructs in a Syngeneic Rat Animal Model
J. P. Beier, U. Kneser, J. Stern-Sträter, G. B. Stark, and A. D. Bach

Use of D-StatTM to Prevent Bleeding Following Percutaneous Transhepatic Intraportal Islet Transplantation
Tatiana Froud, Jose M. Yrizarry, Rodolfo Alejandro, and Camillo Ricordi

Effect of the Embolization of Completely Unpurified Islets on Portal Vein Pressure and Hepatic Biochemistry in Clinical Practice
Sung Ho Hyon, María Candela Ceballos, Mariana Barbich, Rosana Groppa, Luis Grosembacher, María Mercedes Vieiro, Laura Barcan, Salomon Algranati, Leon Litwak, and Pablo F. Argibay

Short-Term Storage of the Ischemically Damaged Human Pancreas by the Two-Layer Method Prior to Islet Isolation
Toshiaki Tsujimura, Yoshikazu Kuroda, Thomas A. Churchill, Jose G. Avila, Tatsuya Kin, A. M. James Shapiro, and Jonathan R. T. Lakey

CD86 Blockade in Genetically Modified Porcine Cells Delays Xenograft Rejection by Inhibiting T-Cell and NK-Cell Activation
Cristina Costa, Maryellen C. Pizzolato, Yamin Shen, Yi Wang, and William L. Fodor

BOOK REVIEW

Dopaminergic Neuron Transplantation in the Weaver Mouse Model of Parkinson's Disease (Lazaros C. Triarhou)
Rania Shamekh, Paul R. Sanberg, and Alison E. Willing