ognizant Communication Corporation

The Regenerative Medicine Journal

VOLUME 15, 2006

VOLUME 15, NUMBER 10, 2006


Naoya Kobayashi, Guest Editor-in-Chief


Cell Therapy for Diabetes Mellitus
Naoya Kobayashi

Functional Hepatocyte Culture and its Application to Cell Therapies
Kimiaki Tanaka, Alejandro Soto-Gutierrez, Nalu Navarro-Alvarez, Jorge David Rivas-Carrillo, Hee-Sook Jun, and Naoya Kobayashi

Original Contributions

Instant Hepatic Differentiation of Human Embryonic Stem Cells Using Activin A and a Deleted Variant of HGF
Yong Chen, Alejandro Soto-Gutierrez, Nalu Navarro-Alvarez, Jorge David Rivas-Carrillo, Tomoki Yamatsuji, Yasuhiro Shirakawa, Noriaki Tanaka, and Naoya Kobayashi

The Significant Improvement of Survival Times and Pathological Parameters by Bioartificial Liver With Recombinant HepG2 in Porcine Liver Failure Model
Shin Enosawa, Tomoyuki Miyashita, Tomohiro Saito, Takeshi Omasa, and Toshiharu Matsumura

Preservation of Rat Aortic Tissue Transplant With Green Tea Polyphenols
S.-H. Hyon, D.-H. Kim, W. Cui, K. Matsumura, J.-Y. Kim, and S. Tsutsumi

Increased Sensitivities of Peripheral Blood Mononuclear Cells to Immunosuppressive Drugs in Cirrhosis Patients Awaiting Liver Transplantation
Abuduxukuer Mijiti, Naoto Matsuno, Tohru Iwahori, Hironori Takeuchi, Takeshi Nagao, Kitaro Oka, and Toshihiko Hirano

Maintenance of Neovascularization at the Implantation Site of an Artificial Device by bFGF and Endothelial Cell Transplant
Atsushi Miki, Jorge D. Rivas-Carrillo, Nalu Navarro-Alvarez, Alejandro Soto-Gutierrez, Yong Chen, Kimiaki Tanaka, Michiki Narushima, Yasuhiko Tabata, Teru Okitsu, Hirofumi Noguchi, Shinichi Matsumoto, Noriaki Tanaka, and Naoya Kobayashi

PuraMatrixTM Facilitates Bone Regeneration in Bone Defects of Calvaria in Mice
Haruo Misawa, Naoya Kobayashi, Alejandro Soto-Gutierrez, Yong Chen, Aki Yoshida, Jorge David Rivas-Carrillo, Nalu Navarro-Alvarez, Kimiaki Tanaka, Atsushi Miki, Jiro Takei, Tadayoshi Ueda, Masato Tanaka, Hirosuke Endo, Noriaki Tanaka, and Toshifumi Ozaki

Improvement of Hepatocyte Viability After Cryopreservation by Supplementation of Long-Chain Oligosaccharide in the Freezing Medium in Rats and Humans
Yoshitaka Miyamoto, Satoshi Suzuki, Kou Nomura, and Shin Enosawa

Self-Assembling Peptide Nanofiber as a Novel Culture System for Isolated Porcine Hepatocytes
Nalu Navarro-Alvarez, Alejandro Soto-Gutierrez, Jorge D. Rivas-Carrillo, Yong Chen, Tsuyoshi Yamamoto, Takeshi Yuasa, Haruo Misawa, Jiro Takei, Noriaki Tanaka, and Naoya Kobayashi

Induction of Pancreatic Stem/Progenitor Cells Into Insulin-Producing Cells by Adenoviral-Mediated Gene Transfer Technology
Hirofumi Noguchi, Gang Xu, Shinichi Matsumoto, Hideaki Kaneto, Naoya Kobayashi, Susan Bonner-Weir, and Shuji Hayashi

Amelioration of Diabetes in Mice After Single-Donor Islet Transplantation Using the Controlled Release of Gelatinized FGF-2
Jorge David Rivas-Carrillo, Nalu Navarro-Alvarez, Alejandro Soto-Gutierrez, Teru Okitsu, Yong Chen, Yasuhiko Tabata, Haruo Misawa, Hirofumi Noguchi, Shinichi Matsumoto, Noriaki Tanaka, and Naoya Kobayashi

Double-Compartment Cell Culture Apparatus: Construction and Biochemical Evaluation for Bioartificial Liver Support
Masahiro Takahashi, Masayuki Sakurai, Shin Enosawa, Takeshi Omasa, Shuichi Tsuruoka, and Toshiharu Matsumura

Volume 15 Subject and Author Index

VOLUME 15, NUMBERS 8/9, 2006

Original Contributions

Autologous Bone Marrow Transplantation in Patients With Subacute and Chronic Spinal Cord Injury
Eva Syková, Ales Homola, Radim Mazanec, Hynek Lachmann, Simona Langkramer Konrádová, Petr Kobylka, Radek Pádr, Jirí Neuwirth, Vladimír Komrska, Vladimír Vávra, Jan Stulík, and Martin Bojar

Transplantation of Bioreactor-Produced Neural Stem Cells Into the Rodent Brain
M. McLeod, M. Hong, A. Sen, D. Sadi, R. Ulalia, L. A. Behie, and I. Mendez

Murine Brain Progenitor Cells Have the Ability to Differentiate Into Functional Neurons and Integrate Into the CNS
Singhua Ding, Conrad A. Messam, Peiying Li, Michael E. Selzer, Marc A. Dichter, and Philip G. Haydon

Immunologic Consequences of Multiple, High-Dose Administration of Allogeneic Mesenchymal Stem Cells to Baboons
Kristin J. Beggs, Alex Lyubimov, Jade N. Borneman, Amelia Bartholomew, Annemarie Moseley, Robert Dodds, Michael P. Archambault, Alan K. Smith, and Kevin R. McIntosh

Human Bone Marrow Mesenchymal Stem Cells Seeded on Modified Collagen Improved Dermal Regeneration In Vivo
Marta Markowicz, Eva Koellensperger, Sabine Neuss, Sarah Koenigschulte, Christine Bindler, and Norbert Pallua

Establishment of Cocultures of Osteoblasts, Schwann Cells, and Neurons Towards a Tissue-Engineered Approach for Orofacial Reconstruction
Kirsten Haastert, Nicole Semmler, Maike Wesemann, Martin Rücker, Nils-Claudius Gellrich, and Claudia Grothe

The Use of the BD Oxygen Biosensor System to Assess Isolated Human Islets of Langerhans: Oxygen Consumption as a Potential Measure of Islet Potency
Chris Fraker, Mark R. Timmins, Richard D. Guarino, Perry D. Haaland, Hirohito Ichii, Damaris Molano, Antonello Pileggi, Raffaella Poggioli, Sharon C. Presnell, Luca Inverardi, Mitra Zehtab, and Camillo Ricordi

Adenovirus-Mediated Expression of the Anticoagulant Hirudin in Human Islets: A Tool to Make the Islets Biocompatible to Blood
Sanja Cabric, Graciela Elgue, Bo Nilsson, Olle Korsgren, and Peter Schmidt

Survival of an Islet Allograft Deficient in iNOS After Implantation Into Diabetic NOD Mice
Andreas Börjesson, Annika K. Andersson, and Stellan Sandler

The Effects of Immunosuppressive Agents on the Function of Human Hepatocytes In Vitro
Trinidad Serrano, Ragai R. Mitry, Claire Terry, Sharon C. Lehec, Anil Dhawan, and Robin D. Hughes

Microencapsulation of Engineered Cells to Deliver Sustained High Circulating Levels of Interleukin-6 to Study Hepatocellular Carcinoma Progression
Diarmuid M. Moran, Leonidas G. Koniaris, Elizabeth M. Jablonski, Paul A. Cahill, Craig R. Halberstadt, and Iain H. McKillop

Enhanced Functional Maturation of Fetal Porcine Hepatocytes in Three-Dimensional Poly-L-lactic Acid Scaffolds: A Culture Condition Suitable for Engineered Liver Tissues in Large-Scale Animal Studies
Hongyun Huang, Sanshiro Hanada, Nobuhiko Kojima, and Yasuyuki Sakai

In Vitro Functionality of Human Fetal Liver Cells and Clonal Derivatives Under Proliferative Conditions
Tanja Deurholt, Lysbeth ten Bloemendaal, Aniska A. Chhatta, Albert C. W. A. van Wijk, Kees Weijer, Jurgen Seppen, Ronald P. J. Oude Elferink, Robert A. F. M. Chamuleau, and Ruurdtje Hoekstra

Development, Characterization, and Use of a Fetal Skin Cell Bank for Tissue Engineering in Wound Healing
Anthony S. De Buys Roessingh, Judith Hohlfeld, Corinne Scaletta, Nathalie Hirt-Burri, Stefan Gerber, Patrick Hohlfeld, Jan-Olaf Gebbers, and Lee Ann Applegate

Induction of Tolerance Across Fully Mismatched Barriers by a Nonmyleoablative Treatment Excluding Antibodies or Irradiation Use
Lionel Stephan, Christophe Pichavant, Manaf Bouchentouf, Philippe Mills, Geoffrey Camirand, Saloua Tagmouti, David Rothstein, and Jacques P. Tremblay

VOLUME 15, NUMBER 7, 2006


Bone Marrow Stromal Cells for Repair of the Spinal Cord: Towards Clinical Application
Rishi D. S. Nandoe, Andres Hurtado, Allan D. O. Levi, Andre Grotenhuis, and Martin Oudega

Original Contributions

Transplanted Human Neural Precursor Cells Migrate Widely But Show no Lesion-Specific Tropism in the 6-Hydroxydopamine Rat Model of Parkinson's Disease
M. Jain, R. J. E. Armstrong, S. Elneil, and R. A. Barker

In Vitro Culture Duration Does Not Impact the Ability of Encapsulated Choroid Plexus Transplants to Prevent Neurological Deficits in an Excitotoxin-Lesioned Rat Model of Huntington's Disease
Dwaine F. Emerich and Christopher G. Thanos

Retinal Progentior Cell Xenografts to the Pig Retina: Immunological Reactions
Karin Warfvinge, Jens F. Kiilgaard, Henry Klassen, Parisa Zamiri, Erik Scherfig, Wayne Streilein, Jan U. Prause, and Michael J. Young

Resolution of Neurotoxicity and b-Cell Toxicity in an Islet Transplant Recipient Following Substitution of Tacrolimus With MMF
Tatiana Froud, David A. Baidal, Gaston Ponte, Jacqueline V. Ferreira, Camillo Ricordi, and Rodolfo Alejandro

Tetracycline-Regulated Expression of VEGF-A in Beta Cells Induces Angiogenesis: Improvement of Engraftment Following Transplantation
Zoltan Mathe, Philippe Dupraz, Chris Rinsch, Bernard Thorens, Domenico Bosco, Marie Zbinden, Philippe Morel, Thierry Berney, and Michael S. Pepper

Transplantation of Murine Bone Marrow Stromal Cells Under the Kidney Capsule to Secrete Coagulation Factor VIII
Taekeun Oh, Alexandra Peister, Kazuo Ohashi, and Frank Park

Human Umbilical Cord Blood Progenitor Cells Are Attracted to Infarcted Myocardium and Significantly Reduce Myocardial Infarction Size
Robert J. Henning, Jose D. Burgos, Leo Ondrovic, Paul Sanberg, John Balis, and Michael B. Morgan

Brief Communication

Use of Repeating Dispensers to Increase the Efficiency of the Intramuscular Myogenic Cell Injection Procedure
Daniel Skuk, Marlyne Goulet, and Jacques P. Tremblay


Cell Transplantation: Toward Cell Therapy
Agneta SanMartin and Cesar V. Borlongan

VOLUME 15, NUMBER 6, 2006


Online Manuscript Processing for Cell Transplantation


Myoblast Therapy: From Bench to Bedside
Zhongmin Liu, Yanling Wu, and Bing-guan Chen

Cell Therapy for Parkinson's Disease: Only Young Onset Patients Allowed? Reflections About the Results of Recent Clinical Trials With Cell Therapy and the Progression of Parkinson's Disease
Gurutz Linazasoro

Original Contributions

Bridging Nigrostriatal Pathway With Fibroblast Growth Factor-Primed Peripheral Nerves and Fetal Ventral Mesencephalon Transplant Recuperates From Deficits in Parkinsonian Rats
Yung-Hsiao Chiang, Shinn-Zong Lin, and Feng C. Zhou

Inhibition of p38 MAP Kinase in the Early Posttransplantation Phase Redistributes Blood Vessels From the Surrounding Stroma Into the Transplanted Endocrine Tissue
Åsa Johansson, Daniel Sandvik, and Per-Ola Carlsson

Isolated Pancreatic Islets in Three-Dimensional Matrices Are Responsive to Stimulators and Inhibitors of Angiogenesis
André Kidszun, Darius Schneider, Doris Erb, Gundula Hertl, Veronika Schmidt, Michael Eckhard, Klaus T. Preissner, Georg Breier, Reinhard G. Bretzel, and Thomas Linn

Endothelial Cell Preservation at 10°C Minimizes Catalytic Iron, Oxidative Stress, and Cold-Induced Injury
Michael A. J. Zieger and Mahesh P. Gupta

Application of a New Subretinal Injection Device in the Dog
András M. Komáromy, Signe E. Varner, Eugene de Juan, Gregory M. Acland, and Gustavo D. Aguirre

Periosteal Cell Pellet Culture System: A New Technique for Bone Engineering
Mari Akiyama, Hidehiko Nonomura, Syed H. Kamil, and Ronald A. Ignotz

Directed Three-Dimensional Growth of Microvascular Cells and Isolated Microvessel Fragments
Carlos C. Chang and James B. Hoying

NECTAR Abstracts
16th Meeting of the Network of European CNS Transplantation and Restoration (NECTAR)

VOLUME 15, NUMBER 5, 2006

Original Contributions

Fate of Embryonic Stem Cells Transplanted Into the Deafened Mammalian Cochlea
B. Coleman, J. Hardman, A. Coco, S. Epp, M. de Silva, J. Crook, and R. Shepherd

Porcine Fetal Ventral Mesencephalic Cells Are Targets for Primed Xenoreactive Human T Cells
Jan Koopmans, Aalzen de Haan, Elinda Bruin, Ieneke van der Gun, Henk van Dijk, Jan Rozing, Lou de Leij, and Michiel Staal

Ectopic Ossification in the Scar Tissue of Rats With Myocardial Infarction
Karla Consort Ribeiro, Elisabete César Mattos, João Pedro Saar Werneck-de-Castro, Vanessa Pinho Ribeiro, Ricardo Henrique Costa-e-Sousa, Amarildo Miranda, Emerson Lopes Olivares, Marcos Farina, José Geraldo Mill, Regina Coeli dos Santos Goldenberg, Masako Oya Masuda, and Antônio Carlos Campos de Carvalho

Suppression of Human T-Cell Responses to ?-Cells by Activation of B7-H4 Pathway
Dawei Ou, Xiaojie Wang, Daniel L. Metzger, Ziliang Ao, Paolo Pozzilli, Roger F. L. James, Lieping Chen, and Garth L. Warnock

Regeneration of Osteonecrosis of Canine Scapho-lunate Using Bone Marrow Stromal Cells: Possible Therapeutic Approach for Kienböck Disease
Ryosuke Ikeguchi, Ryosuke Kakinoki, Tomoki Aoyama, Kotaro Roberts Shibata, Seiji Otsuka, Kennichi Fukiage, Koichi Nishijo, Tatsuya Ishibe, Yasuko Shima, Bungo Otsuki, Takashi Azuma, Sadami Tsutsumi, Tomitaka Nakayama, Takanobu Otsuka, Takashi Nakamura, and Junya Toguchida

Assessment of In Vitro Applicability of Reversibly Immortalized NKNT-3 Cells and Clonal Derivatives
Ruurdtje Hoekstra, Tanja Deurholt, Lysbeth ten Bloemendaal, Mireille Desille, Albert C. W. A. van Wijk, Bruno Clement, Ronald P. J. Oude Elferink, Thomas M. van Gulik, and Robert A. F. M. Chamuleau

A Novel Bioreactor Miccrocarrier Cell Culture System for High Yields of Proliferating Autologous Human Keratinocytes
Jin Yu Liu, Jürg Hafner, Galya Dragieva, and Günter Burg

High Yields of Autologous Living Dermal Equivalents Using Porcine Gelatin Microbeads as Microcarriers for Autologous Fibroblasts
Jin Yu Liu, Jürg Hafner, Galya Dragieva, and Günter Burg

VOLUME 15, NUMBER 4, 2006

Original Contribution

Neural Transplantation in Huntington's Disease: The NEST-UK Donor Tissue Microbiological Screening Program and Review of the Literature
M. Farrington, T. G. Wreghitt, A. M. L. Lever, S. B. Dunnett, A. E. Rosser, and R. A. Barker


Chemokines and Their Receptors in Islet Allograft Rejection and as Targets for Tolerance Induction
Shaheed Merani, Wayne Truong, Wayne W. Hancock, Colin C. Anderson, and A. M. James Shapiro

Original Contributions

Porcine Islet Graft Function Is Affected by Pretreatment With a Caspase-3 Inhibitor
Daniel Brandhorst, Vidya Kumarasamy, Adel Maatoui, Alexandra Alt, Reinhard G. Bretzel, and Heide Brandhorst

Survival and Function of Transplanted Islet Cells on an In Vivo, Vascularized Tissue Engineering Platform in the Rat: A Pilot Study
David L. Brown, Peter J. Meagher, Kenneth R. Knight, Effie Keramidaris, Rosalind Romeo-Meeuw, Anthony J. Penington, and Wayne A. Morrison

Maintenance of Mouse, Rat, and Pig Pancreatic Islet Functions by Coculture With Human Islet-Derived Fibroblasts
Atsushi Miki, Michiki Narushima, Teru Okitsu, Yuichi Takeno, Alejandro Soto-Gutierrez, Jorge David Rivas-Carrillo, Nalé Navarro-Alvarez, Yong Chen, Kimiaki Tanaka, Hirofumi Noguchi, Shinichi Matsumoto, Michinori Kohara, Jonathan R. T. Lakey, Eiji Kobayashi, Noriaki Tanaka, and Naoya Kobayashi

Differentiation of Human Embryonic Stem Cells to Hepatocytes Using Deleted Variant of HGF and Poly-amino-urethane-Coated Nonwoven Polytetrafluoroethylene Fabric
Alejandro Soto-Gutierrez, Nalú Navarro-Alvarez, Jorge David Rivas-Carrillo, Yong Chen, Tomoki Yamatsuji, Noriaki Tanaka, and Naoya Kobayashi

The Development and Characterization of an HEK293-Derived Cell Line for Use in an Intratumoral Cytokine Delivery System
M. J. Hamilton, Q. X. Huang, C. L. Li, and K. A. O. Ellem

Short-Term Heart Retention and Distribution of Intramyocardial Delivered Mesenchymal Cells Within Necrotic or Intact Myocardium
Nguyen Tran, Yan Li, Fatiha Maskali, Laurent Antunes, Pablo Maureira, Marie-Helene Laurens, Pierre-Yves Marie, Gilles Karcher, Frederique Groubatch, Jean-François Stoltz, and Jean-Pierre Villemot

Brief Communication

Survival of Microencapsulated Islets at 400 Days Posttransplantation in the Omental Pouch of NOD Mice
Tsunehiro Kobayashi, Yukio Aomatsu, Hiroo Iwata, Tatsuya Kin, Hiromichi Kanehiro, Michiyoshi Hisanga, Saiho Ko, Mitsuo Nagao, George Harb, and Yoshiyuki Nakajima




Bruno Gridelli

End-Stage Organ Failure: Will Regenerative Medicine Keep Its Promise?
Fabio Triolo and Bruno Gridelli

Tissue Engineering and the Challenges Within
Sara L. Wargo, Thangappan Ravi Kumar, and Alan J. Russell

Development of Composite Porous Scaffolds Based on Collagen and Biodegradable Poly(ester urethane)urea
Jianjun Guan, John J. Stankus, and William R. Wagner

The Use of Extracellular Matrix as an Inductive Scaffold for the Partial Replacement of Functional Myocardium
Stephen F. Badylak, Paul V. Kochupura, Ira S. Cohen, Sergey V. Doronin, Adam E. Saltman, Thomas W. Gilbert, Damon J. Kelly, Ronald A. Ignotz, and Glenn R. Gaudette

Growth Factor Enhancement of Cardiac Regeneration
Nadia Rosenthal, Maria Paola Santini, and Antonio Musarò

Stem Cell Therapy for Ischemic Heart Disease: Beginning or End of the Road?
Christof Stamm, Andreas Liebold, Gustav Steinhoff, and Dirk Strunk

Wound Healing in the Biliary Tree of Liver Allografts
A. J. Demetris, Paulo Fontes, John G. Lunz, III, Susan Specht, Noriko Murase, and Amadeo Marcos

Flexible Lineage Specifications of Adult Hepatic Cells, Associated Molecular Pathways, and Their Relationship to Liver Cancer
George K. Michalopoulos

Towards the Development of a Pediatric Ventricular Assist Device
Harvey S. Borovetz, Stephen Badylak, J. Robert Boston, Carl Johnson, Robert Kormos, Marina V. Kameneva, Marwan Simaan, Trevor A. Snyder, Hiro Tsukui, William R. Wagner, Joshua Woolley, James Antaki, Chenguang Diao, Stijn Vandenberghe, Bradley Keller, Victor Morell, Peter Wearden, Steven Webber, Jeff Gardiner, Chung M. Li, Dave Paden, Bradley Paden, Shaun Snyder, Jingchun Wu, Gill Bearnson, John A. Hawkins, Gordon Jacobs, John Kirk, Pratap Khanwilkar, Peter C. Kouretas, James Long, and R. E. Shaddy

Is Facilitating Pancreatic Beta Cell Regeneration a Valid Option for Clinical Therapy?
Massimo Trucco

Protein Transduction: A Novel Approach to Induce In Vitro Pancreatic Differentiation
Juan Domínguez-Bendala, Ricardo L. Pastori, Camillo Ricordi, and Luca Inverardi

Bioreactors for Extracorporeal Liver Support
Jörg C. Gerlach

Hepatocyte Transplantation: Clinical Experience and Potential for Future Use
Stephen C. Strom, Paolo Bruzzone, Hongbo Cai, Ewa Ellis, Thomas Lehmann, Keitaro Mitamura, and Toshio Miki

The Regenerative Potential of Stem Cells in Acute Renal Failure
Marina Morigi, Ariela Benigni, Giuseppe Remuzzi, and Barbara Imberti

Vascular Tissue Engineering
Chiara Arrigoni, Davide Camozzi, and Andrea Remuzzi


VOLUME 15, NUMBER 3, 2006


Repairing the Nervous System: A Special Issue Based on the 12th Annual American Society for Neural Therapy and Repair (ASNTR) Meeting
Kathy Steece-Collier

Original Contributions

Timing of Cord Blood Treatment After Experimental Stroke Determines Therapeutic Efficacy
Jennifer D. Newcomb, Craig T. Ajmo, Jr., Cyndy D. Sanberg, Paul R. Sanberg, Keith R. Pennypacker, and Alison E. Willing

Genetically Engineered Human Mesenchymal Stem Cells Produce Met-Enkephalin at Augmented Higher Levels In Vitro
Ikuko Sugaya, Tingyu Qu, Kiminobu Sugaya, and George D. Pappas

Behavioral and Histological Characterization of Intrahippocampal Grafts of Human Bone Marrow-Derived Multipotent Progenitor Cells in Neonatal Rats With Hypoxic-Ischemic Injury
Takao Yasuhara, Noriyuki Matsukawa, Guolong Yu, Lin Xu, Robert W. Mays, Jim Kovach, Robert J. Deans, David C. Hess, James E. Carroll, and Cesar V. Borlongan


Progressive Dopamine Neuron Loss in Parkinson's Disease: The Multiple Hit Hypothesis
Paul M. Carvey, Ashok Punati, and Mary B. Newman

Neural Repair Strategies for Parkinson's Disease: Insights From Primate Models
Katherine Soderstrom, Jennifer O'Malley, Kathy Steece-Collier, and Jeffrey H. Kordower

CNS Gene Therapy and a Nexus of Complexity: Systems and Biology at a Crossroads
Carolyn M. Tyler and Howard J. Federoff


Additional Abstracts for the 13th Annual Meeting of the American Society for Neural Therapy and Repair

VOLUME 15, NUMBER 2, 2006


Pig-to-Nonhuman Primate Islet Xenotransplantation: A Review of Current Problems
P. P. M. Rood, L. H. Buhler, R. Bottino, M. Turcco, and D. K. C. Cooper

Coinhibitory T-Cell Signaling in Islet Allograft Rejection and Tolerance
Wayne Truong, Wayne W. Hancock, Colin C. Anderson, Shaheed Merani, and A. M. James Shapiro

Original Contributions

Viability and Functionality of Bovine Chromaffin Cells Encapsulated Into Alginate-PLL Microcapsules With a Liquefied Inner Core
T. Moustafa, S. Girod, F. Tortosa, R. Li, J.C. Sol, F. Rodriguez, R. Bastide, Y. Lazorthes, and B. Sallerin

One-Step Induction of Neurons From Mouse Embryonic Stem Cells in Serum-Free Media Containing Vitamin B12 and Heparin
Hironori Yamazoe, Masato Kobori, Yoshinobu Murakami, Keiichi Yano, Mitsuo Satoh, Kenji Mizuseki, Yoshiki Sasai, and Hiroo Iwata

Engrafted Neural Progenitor Cells Express a Tissue-Restricted Reporter Gene-Associated With Differentiated Retinal Photoreceptor Cells
Thien N. Sam, Jing Xiao, Heidi Roehrich, Walter C. Low, and Dale S. Gregerson

Subnormothermic Preservation Maintains Viability and Function in a Porcine Hepatocyte Culture Model Simulating Bioreactor Transport
M.-P. van de Kerkhove, R. Hoekstra, F. C. van Nooijen, F. O. B. Spoelstra, B. M. Doorschodt, A. C. W. A. van Wijk, P. P. C. Poyck, R. A. F. M. Chamuleau, and T. M. van Gulik

Quantitative Assay for Quality Assurance of Human Cells for Clinical Transplantation
Steven T. Boyce, Benjamin A. Anderson, and Horacio L. Rodriguez-Rilo

Comparison of Cooling Systems During Islet Purification
Sue Swift, Tatsuya Kin, Mohammadreza Mirbolooki, Richard Wilson, and Jonathan R. T. Lakey

Estimation of Pancreas Weight From Donor Variables
Tatsuya Kin, Travis B. Murdoch, A. M. James Shapiro, and Jonathan R. T. Lakey

Ameliorating Injury During Preservation and Isolation of Human Islets Using the Two-Layer Method With Perfluorocarbon and UW Solution
Payam Salehi, Mohammadreza Mirbolooki, Tatsuya Kin, Toshiaki Tsujimura, A. M. James Shapiro, Thomas A. Churchill, and Jonathan R. T. Lakey

Functional MR Microimaging of Pancreatic b-Cell Activation
Barjor Gimi, Lara Leoni, Jose Oberholzer, Mark Braun, Jose Avila, Yong Wang, Tejal Desai, Louis H. Philipson, Richard L. Magin, and Brian B. Roman

Brief Communication

Size-Dependent Revascularization of Transplanted Pancreatic Islets
Caroline Kampf, Göran Mattsson, and Per-Ola Carlsson

VOLUME 15, NUMBER 1, 2006

Original Contributions

Genetic Modification of Hepatocytes Towards Hepatocyte Transplantation and Liver Tissue Engineering
Hiroyuki Kuge, Kazuo Ohashi, Takashi Yokoyama, Hiromichi Kanehiro, Michiyoshi Hisanaga, Fumikazu Koyama, Ginny L. Bumgardner, Ken-Ichiro Kosai, and Yoshiyuki Nakajima

Hepatocyte Transplantation in the Long Evans Cinnamon Rat Model of Wilson's Disease
Seon Mee Park, Kim Vo, Michel Lallier, Alexis-Simon Cloutier, Pierre Brochu, Fernando Alvarez, and Steven R. Martin

Cryopreserved Fetal Liver Cell Transplants Support the Chronic Failing Liver in Rats With CCl4-Induced Cirrhosis
Olga V. Ochenashko, Nataliya A. Volkova, Svetlana P. Mazur, Alexander Yu. Somov, Barry J. Fuller, and Alexander Yu. Petrenko

Analysis of the Effects of Cryopreservation on Rat Hepatocytes Using SELDI-TOF Mass Spectrometry
Claire Terry, Matthew Bailey, Ragai R. Mitry, Sharon C. Lehec, Anil Dhawan, and Robin D. Hughes

Sertoli Cells Induce Systemic Donor-Specific Tolerance in Xenogenic Transplantation Model
R. Shamekh, N. S. El-Badri, S. Saporta, C. Pascual, P. R. Sanberg, and D. F. Cameron

Effects of Simulated Microgravity on the Morphology and Function of Neonatal Porcine Cell Clusters Cultured With and Without Sertoli Cells
G. Luca, M. Calvitti, C. Nastruzzi, G. Macchiarulo, E. Becchetti, L. M. Neri, S. Capitani, G. Basta, P. Brunetti, R. Calafiore, and D. F. Cameron

Engineered Cell Therapy for Sustained Local Myocardial Delivery of Nonsecreted Proteins
Jing Bian, Matt Kiedrowski, Niladri Mal, Farhad Forudi, and Marc S. Penn

Molecular Imaging Reveals Skeletal Engraftment Sites of Transplanted Bone Marrow Cells
Philipp Mayer-Kuckuk, Mikhail Doubrovin, Luc Bidaut, Tulin Budak-Alpdogan, Shangde Cai, Vanessa Hubbard, Onder Alpdogan, Marcel van den Brink, Joseph R. Bertino, Ronald G. Blasberg, Debabrata Banerjee, and Juri Gelovani

Book Reviews

Bone Morphogenetic Protein and Collagen (Glyn O. Phillips, editor)
Deana Hussamy and John T. Sinnott

Epidermal Cells: Methods and Protocols (Kursad Turksen, editor)
Deepak Agrawal

Stem Cells in Endocrinology (Linda B. Lester, editor)
Niketa A. Patel