ognizant Communication Corporation

The Regenerative Medicine Journal

VOLUME 18, 2009



Current Status of Stem Cell Therapy for Liver Diseases
Bruno Solano de Freitas Souza, Renata Campos Nogueira, Sheilla Andrade de Oliveira, Luiz Antonio Rodrigues de Freitas, Luiz Guilherme Costa Lyra, Ricardo Ribeiro dos Santos, Andre Castro Lyra, and Milena Botelho Pereira Soares

Original Contributions

E-Cadherin Protects Primary Hepatocyte Spheroids From Cell Death by a Caspase-Independent Mechanism
Jennifer L. Luebke-Wheeler, Geir Nedredal, Le Yee, Bruce P. Amiot, and Scott L. Nyberg

Functional Impact of Targeted Closed-Chest Transplantation of Bone Marrow Cells in Rats With Acute Myocardial Ischemia/Reperfusion Injury
Alexander Ghanem, Agnieszka Ziomka, Benjamin Krausgrill, Kerstin Schenk, Clemens Troatz, Tomas Miszalski-Jamka, Georg Nickenig, Klaus Tiemann, and Jochen Müller-Ehmsen

Refractory Angina Cell Therapy (ReACT) Involving Autologous Bone Marrow Cells in Patients Without Left Ventricular Dysfunction: A Possible Role for Monocytes
Nelson Americo Hossne, Jr., Adriana Luckow Invitti, Enio Buffolo, Silvia Azevedo, José Salvador Rodrigues de Oliveira, Noedir Groppo Stolf, L. Eduardo Cruz, and Paul R. Sanberg

Increased Apelin Following Bone Marrow Mononuclear Cell Transplantation Contributes to the Improvement of Cardiac Function in Patients With Severe Heart Failure
Lian Ru Gao, Ru Yi Xu, Ning Kun Zhang, Yu Chen, Zhi Guo Wang, Zhi Ming Zhu, Yu Xing Fei, Yi Cao, Hong Tao Xu, and Ye Yang

Sequential Hepatogenic Transdifferentiation of Adipose Tissue-Derived Stem Cells: Relevance of Different Extracellular Signaling Molecules, Transcription Factors Involved, and Expression of New Key Marker Genes
A. Bonora-Centelles, R. Jover, V. Mirabet, A. Lahoz, F. Carbonell, J. V. Castell, and M. J. Gómez-Lechón

Use of Transduced Adipose Tissue Stromal Cells as Biologic Minipumps to Deliver Levodopa for the Treatment of Neuropathic Pain: Possibilities and Limitations
Nuria Cobacho, Ana Belén Serrano, Maria José Casarejos, Mari Angeles Mena, and Carlos Luis Paíno

Functional Recovery After the Transplantation of Neurally Differentiated Mesenchymal Stem Cells Derived From Bone Barrow in a Rat Model of Spinal Cord Injury
Sung-Rae Cho, Yong Rae Kim, Hoi-Sung Kang, Sun Hee Yim, Chang-il Park, Yoo Hong Min, Bae Hwan Lee, Ji Cheol Shin, and Jong-Baeck Lim

Intravenous Administration of 99mTc-HMPAO-Labeled Human Mesenchymal Stem Cells After Stroke: In Vivo Imaging and Biodistribution
Olivier Detante, Anaïck Moisan, Julien Dimastromatteo, Marie-Jeanne Richard, Laurent Riou, Emmanuelle Grillon, Emmanuel Barbier, Marie-Dominique Desruet, Florence De Fraipont, Christoph Segebarth, Assia Jaillard, Marc Hommel, Catherine Ghezzi, and Chantal Remy

TNF, Pig CD86, and VCAM-1 Identified as Potential Targets for Intervention in Xenotransplantation of Pig Chondrocytes
Roberta Sommaggio, Rafael Máñez, and Cristina Costa

Secreted Products From the Porcine Choroid Plexus Accelerate the Healing of Cutaneous Wounds
C. G. Thanos, D. F. Emerich, B. E. Bintz, M. Goddard, J. Mills, R. Jensen, M. Lombardi, S. Hall, and K. Boekelheide

Volume 18 Subject and Author Index



Protocols for Hematopoietic Stem Cell Expansion From Umbilical Cord Blood
Sonja Koestenbauer, Andreas Zisch, Gottfried Dohr, and Nicolas H. Zech

Original Contributions

Deleterious Effect of Human Umbilical Cord Blood Mononuclear Cell Transplantation on Thioacetamide-Induced Chronic Liver Damage in Rats
Ana I. Álvarez-Mercado, María V. García-Mediavilla, Sonia Sánchez-Campos, Francisco Abadía, María J. Sáez-Lara, María Cabello-Donayre, Ángel Gil, Javier González-Gallego, and Luis Fontana

Impaired Hepatocyte Regeneration in Acute Severe Hepatic Injury Enhances Effective Repopulation by Transplanted Hepatocytes
Chun-Hsien Yu, Hui-Ling Chen, Ya-Hui Chen, Ming-Fu Chang, Chin-Sung Chien, and Mei-Hwei Chang

Human Multipotent Mesenchymal Stromal Cells From Fetal Lung Expressing Pluripotent Markers and Differentiating Into Cell Types of Three Germ Layers
Cuiling Zheng, Shaoguang Yang, Zhenxing Guo, Wenbin Liao, Lei Zhang, Renchi Yang, and Zhong Chao Han

Transcatheter Injection-Induced Changes in Human Bone Marrow-Derived Mesenchymal Stem Cells
Boon C. Heng, Steven H. Hsu, Catherine M. Cowan, Annie Liu, Julie Tai, Yen Chan, Warren Sherman, and Shubhayu Basu

Oscillating Pressure Treatment Upregulates Connexin43 Expression in Skeletal Myoblasts and Enhances Therapeutic Efficacy for Myocardial Infarction
Sae-Won Lee, Hyun-Jae Kang, Ji-Young Lee, Seock-Won Youn, Joo-Yun Won, Ji-Hyun Kim, Hyun-Chae Lee, Eun Ju Lee, Se-il Oh, Byung-Hee Oh, Young-Bae Park, and Hyo-Soo Kim

Sex of Muscle Stem Cells Does Not Influence Potency for Cardiac Cell Therapy
Lauren Drowley, Masaho Okada, Thomas R. Payne, Gregory P. Botta, Hideki Oshima, Bradley B. Keller, Kimimasa Tobita, and Johnny Huard

Amniotic Membrane Patching Promotes Ischemic Rat Heart Repair
Anna Cargnoni, Marco Di Marcello, Marino Campagnol, Claudia Nassuato, Alberto Albertini, and Ornella Parolini

Local Delivery of Autologous Platelet in Collagen Matrix Simulated In Situ Articular Cartilage Repair
Yi Ying Qi, Xiao Chen, Yang Zi Jiang, Hong Xin Cai, Lin Lin Wang, Xing Hui Song, Xiao Hui Zou, and Hong Wei Ouyang

Transient Recovery in a Rat Model of Familial Amyotrophic Lateral Sclerosis After Transplantation of Motor Neurons Derived From Mouse Embryonic Stem Cells
Rodrigo López-González, Philip Kunckles, and Iván Velasco

Compacted DNA Nanoparticle Gene Transfer of GDNF to the Rat Striatum Enhances the Survival of Grafted Fetal Dopamine Neurons
David M. Yurek, Anita M. Flectcher, Tomasz H. Kowalczyk, Linas Padegimas, and Mark J. Cooper

Cellular Epigenetic Modifications of Neural Stem Cell Differentiation
Rabindra P. Singh, Kevin Shiue, Dominic Schomberg, and Feng C. Zhou

Immune Cell Populations in Nonhuman Primate Islets
Lane C. K. Coffey, Dora M. Berman, Melissa A. Willman, and Norma S. Kenyon

Quantitative Assessment of Islet Cell Products: Estimating the Accuracy of the Existing Protocol and Accounting for Islet Size Distribution
Peter Buchwald, Xiaojing Wang, Aisha Khan, Andres Bernal, Chris Fraker, Luca Inverardi, and Camillo Ricordi

Antiapoptotic Effect of Tacrolimus on Cytokine-Challenged Human Islets
José M. Balibrea del Castillo, M. Cruz García-Martín, Javier Arias-Díaz, Elena Giné, Elena Vara, and José L. Balibrea Cantero

Long-Term Metabolic and Hormonal Effects of Exenatide on Islet Transplant Recipients With Allograft Dysfunction
Raquel N. Faradji, Tatiana Froud, Shari Messinger, Kathy Monroy, Antonello Pileggi, Davide Mineo, Thipaporn Tharavanij, Armando J. Mendez, Camillo Ricordi, and Rodolfo Alejandro



The First Pan Pacific Symposium of Stem Cell Research
Shinn-Zong Lin

Review of Lithium Effects on Brain and Blood
Wise Young

Recent Advances of Dendritic Cells (DCs)-Based Immunotherapy for Malignant Gliomas
Der-Yang Cho, Shinn-Zong Lin, Wen-Kuang Yang, Den-Mei Hsu, Han-Chung Lee, Wen-Yeun Lee, and Shih-Ping Liu

Human Umbilical Cord Blood Cell Grafts for Brain Ischemia
Dong-Hyuk Park, Cesar V. Borlongan, Alison E. Willing, David J. Eve, L. Eduardo Cruz, Cyndy D. Sanberg, Yong-Gu Chung, and Paul R. Sanberg

Gene and Stem Cell Therapy in Ischemic Stroke
Toru Yamashita, Kentaro Deguchi, Shoko Nagotani, Tatsushi Kamiya, and Koji Abe

Transplantation of Endothelial Progenitor Cells as Therapeutics for Cardiovascular Diseases
Huey-Shan Hung, Woei-Cherng Shyu, Chang-Hai Tsai, Shan-hui Hsu, and Shinn-Zong Lin

Mesenchymal Stem Cell Therapy for Nonmusculoskeletal Diseases: Emerging Applications
Tom K. Kuo, Jennifer H. Ho, and Oscar K. Lee

Alternative Splicing Modulates Stem Cell Differentiation
Ru-Huei Fu, Shih-Ping Liu, Chen-Wei Ou, Hsiu-Hui Yu, Kuo-Wei Li, Chang-Hai Tsai, Woei-Cherng Shyu, and Shinn-Zong Lin

MicroRNAs Regulation Modulated Self-Renewal and Lineage Differentiation of Stem Cells
Shih-Ping Liu, Ru-Huei Fu, Hsiu-Hui Yu, Kuo-Wei Li, Chang-Hai Tsai, Woei-Cherng Shyu, and Shinn-Zong Lin

Forever Young: How to Control the Elongation, Differentiation, and Proliferation of Cells Using Nanotechnology
R. G. Ellis-Behnke, Y. X. Liang, J. Guo, D. K. C. Tay, G. E. Schneider, L. A. Teather, W. Wu, and K. F. So


Brief Communication

Laser Capture Microdissection as a New Tool to Assess Graft-Infiltrating Lymphocytes Gene Profile in Islet Transplantation
A. Vergani, B. Clissi, F. Sanvito, C. Doglioni, P. Fiorina, and R. Pardi

Original Contributions

Different Effects of FK506, Rapamycin, and Mycophenolate Mofetil on Glucose-Stimulated Insulin Release and Apoptosis in Human Islets
James D. Johnson, Ziliang Ao, Peter Ao, Hong Li, Long-Jun Dai, Zehua He, May Tee, Kathryn J. Potter, Agnieszka M. Klimek, R. Mark Meloche, David M. Thompson, C. Bruce Verchere, and Garth L. Warnock

Influence of Cell Treatment With PDGF-BB and Reperfusion on Cardiac Persistence of Mononuclear and Mesenchymal Bone Marrow Cells After Transplantation Into Acute Myocardial Infarction in Rats
Benjamin Krausgrill, Marius Vantler, Volker Burst, Martin Raths, Marcel Halbach, Konrad Frank, Silke Schynkowski, Kerstin Schenk, Jürgen Hescheler, Stephan Rosenkranz, and Jochen Müller-Ehmsen

Autologous Umbilical Cord Blood Mononuclear Cell Transplantation Preserves Right Ventricular Function in a Novel Model of Chronic Right Ventricular Volume Overload
Can Yerebakan, Eugen Sandica, Stephanie Prietz, Christian Klopsch, Murat Ugurlucan, Alexander Kaminski, Sefer Abdija, Björn Lorenzen, Johannes Boltze, Björn Nitzsche, Dietmar Egger, Malte Barten, Dario Furlani, Nan Ma, Brigitte Vollmar, Andreas Liebold, and Gustav Steinhoff

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Attenuate Hyperoxia-Induced Lung Injury in Neonatal Rats
Yun Sil Chang, Wonil Oh, Soo Jin Choi, Dong Kyung Sung, Soo Yoon Kim, Eun Yang Choi, Saem Kang, Hye Jin Jin, Yoon Sun Yang, and Won Soon Park

Copper Modulates the Differentiation of Mouse Hematopoietic Progenitor Cells in Culture
Xiaosong Huang, L. Jeanne Pierce, Paul A. Cobine, Dennis R. Winge, and Gerald J. Spangrude

Amniotic Mesenchymal Tissue Cells Inhibit Dendritic Cell Differentiation of Peripheral Blood and Amnion Resident Monocytes
Marta Magatti, Silvia De Munari, Elsa Vertua, Claudia Nassauto, Alberto Albertini, Georg S. Wengler, and Ornella Parolini

Effects of Mechanical Stretch on Collagen and Cross-Linking in Engineered Blood Vessels
Amy Solan, Shannon L. M. Dahl, and Laura E. Niklason

Enhanced Early Tissue Regeneration After Matrix-Assisted Autologous Mesenchymal Stem Cell Transplantation in Full Thickness Chondral Defects in a Minipig Model
Martin Jung, Balazs Kaszap, Anna Redöhl, Eric Steck, Steffen Breusch, Wiltrud Richter, and Tobias Gotterbarm

Small Agarose Microcapsules With Cell-Enclosing Hollow Core for Cell Therapy: Transplantation of Ifosfamide-Activating Cells to the Mice With Preestablished Subcutaneous Tumor
Shinji Sakai, Ichiro Hashimoto, Shinji Tanaka, Brian Salmons, and Koei Kawakami

Experience of Microbiological Screening of Human Hepatocytes for Clinical Transplantation
Sharon C. Lehec, Robin D. Hughes, Ragai R. Mitry, Michelle A. Graver, Anita Verma, Jim J. Wade, and Anil Dhawan



STEPS Toward the Right Direction
John R. Sladek and Paul R. Sanberg


Who's in Favor of Translational Cell Therapy for Stroke: STEPS Forward Please?
Michael Chopp, Gary K. Steinberg, Douglas Kondziolka, Mei Lu, Tonya M. Bliss, Yi Li, David C. Hess, and Cesario V. Borlongan


Cell-Based Therapy for Heart Failure: Skeletal Myoblasts
Monika Seidel, Aleksandra Borczynska, Natalia Rozwadowska, and Maciej Kurpisz

Original Contributions

Overexpression of Follistatin in Human Myoblasts Increases Their Proliferation and Differentiation, and Improves the Graft Success in SCID Mice
B. F. Benabdallah, M. Bouchentouf, J. Rousseau, and J. P. Tremblay

Growth Factor Coinjection Improves the Migration Potential of Monkey Myogenic Precursors Without Affecting Cell Transplantation Success
Jean-François Lafreniere, Marie-Christine Caron, Daniel Skuk, Marlyne Goulet, Anissa Rahma Cheikh, and Jacques P. Tremblay

A Biocompatible Endothelial Cell Delivery System for In Vitro Tissue Engineering
Eun Jung Lee, Gordana Vunjak-Novakovic, Yadong Wang, and Laura E. Niklason

Pig Pancreas Oxygenation at 20°C Increases Islet ATP Generation but Deteriorates Islet Function
M. Iken, H. Brandhorst, O. Korsgren, and D. Brandhorst

2007 Update on Allogeneic Islet Transplantation From the Collaborative Islet Transplant Registry (CITR)
The CITR Research Group

Gender-Dependent Survival of Allogeneic Trophoblast Stem Cells in Liver
Jessica Epple-Farmer, Bisrat G. Debeb, Oliver Smithies, and Bert Binas

Liver Cell Transplantation: Basic Investigations for Safe Application in Infants and Small Children
Jochen Meyburg, Krassimira Alexandrova, Marc Barthold, Sabine Kafert-Kasting, Andrea S. Schneider, Masoumeh Attaran, Friederike Hoerster, Jan Schmidt, Georg F. Hoffmann, and Michael Ott

Primate Adult Brain Cell Autotransplantation, a Pilot Study in Asymptomatic MPTP-Treated Monkeys
Jean-François Brunet, D. Eugene Redmond, Jr., and Jocelyne Bloch

Reversal of Dopaminergic Degeneration in a Parkinsonian Rat Following Micrografting of Human Bone Marrow-Derived Neural Progenitors
Aleksandra Glavaski-Joksimovic, Tamas Virag, Qin A. Chang, Neva C. West, Thomas A. Mangatu, Michael P. McGrogan, Millicent Dugich-Djordjevic, and Martha C. Bohn

Functional Engraftment of the Medial Ganglionic Eminence Cells in Experimental Stroke Model
Marcel M. Daadi, Sang Hyung Lee, Ahmet Arac, Brad A. Grueter, Rishi Bhatnagar, Anne-Lise Maag, Bruce Schaar, Robert C. Malenka, Theo D. Palmer, and Gary K. Steinberg


Regenerative Medicine for Diabetes Mellitus
Naoya Kobayashi, Takeshi Yuasa, and Teru Okitsu

Pancreas Preservation by the Two-Layer Method: Does it Have a Beneficial Effect Compared With Simple Preservation in University of Wisconsin Solution?
Hirofumi Noguchi, Marlon F. Levy,Naoya Kobayashi, and Shinichi Matsumoto

Beneficial Storage Effects of Epigallocatechin-3-O-Gallate on the Articular Cartilage of Rabbit Osteochondral Allografts
Jung Yoon Bae, Kazuaki Matsumura, Shigeyuki Wakitani,Amu Kawaguchi, Sadami Tsutsumi, and Suong-Hyu Hyon

Long-Term Preservation of Rat Skin Tissue by Epigallocatechin-3-O-Gallate
HakHee Kim, Takeshi Kawazoe, Kazuaki Matsumura,Shigehiko Suzuki, and Suong-Hyu Hyon

Preservation of Platelets by Adding Epigallocatechin-3-O-Gallate to Platelet Concentrates
Kazuaki Matsumura, Hiroshi Takayama, Jung Yoon Bae,Mitsuru Kurihara, Sadami Tsutsumi, and Suong-Hyu Hyon

A Study on the Perfusion Preservation, Resuscitation, and Transplantation of a Rat Heart Isolated for 96 Hours
Naoyuki Hatayama, Yu Yoshida, and Kunihiro Seki

Study on the Preservation With CO (PCO = 200-2,000 hPa), Resuscitation, and Heterotopic Transplantation of an Isolated Rat Heart
Yu Yoshida, Naoyuki Hatayama, and Kunihiro Seki

Comparison of Trypsin Inhibitors in Preservation Solution for Islet Isolation
Hirofumi Noguchi, Michiko Ueda, Shuji Hayashi,Naoya Kobayashi, Teru Okitsu, Yasuhiro Iwanaga, Hideo Nagata,Xiaoling Liu, Hiroki Kamiya, Marlon F. Levy, and Shinichi Matsumoto

Estimation of Donor Usability for Islet Transplantation in the United States With the Kyoto Islet Isolation Method
Shinichi Matsumoto, Hirofumi Noguchi, Nobuyo Hatanaka,Masayuki Shimoda, Naoya Kobayashi, Andrew Jackson,Nicholas Onaca,Bashoo Naziruddin, and Marlon F. Levy

SUITO Index for Evaluation of Efficacy of Single Donor Islet Transplantation
Shinichi Matsumoto, Hirofumi Noguchi, Nobuyo Hatanaka,Masayuki Shimoda, Naoya Kobayashi, Andrew Jackson,Nicholas Onaca,Bashoo Naziruddin, and Marlon F. Levy

Establishment of Mouse Pancreatic Stem Cell Line
Hirofumi Noguchi, Koichi Oishi, Michiko Ueda,Hiroshi Yukawa, Shuji Hayashi, Naoya Kobayashi, Marlon F. Levy, and Shinichi Matusmoto

Recombinant Sendai Virus-Mediated Gene Transfer to Mouse Pancreatic Stem Cells
Koichi Oishi, Hirofumi Noguchi, Hiroshi Yukawa,Makoto Inoue, Soichi Takagi, Hisashi Iwata, Mamoru Hasegawa, and Shuji Hayashi

Differential Ability of Somatic Stem Cells
Koichi Oishi, Hirofumi Noguchi, Hiroshi Yukawa, and Shuji Hayashi

Quantum Dots for Labeling Adipose Tissue-Derived Stem Cells
Hiroshi Yukawa, Shogo Mizufune, Chiharu Mamori,Yukimasa Kagami, Koichi Oishi, Noritada Kaji, Yukihiro Okamoto,Manabu Takeshi, Hirofumi Noguchi, Yoshinobu Baba,Michinari Hamaguchi, Nobuyuki Hamajima, and Shuji Hayashi

Comparison of Sendai Virus-Mediated Gene Transfer Efficiency to Adhesive and Floating Adipose Tissue-Derived Stem Cells
Hiroshi Yukawa, Hirofumi Noguchi, Koichi Oishi,Makoto Inoue, Mamoru Hasegawa, Michinari Hamaguchi,Nobuyuki Hamajima, and Shuji Hayashi

Cell Transplantation of Adipose Tissue-Derived Stem Cells in Combination With Heparin Attenuated Acute Liver Failure in Mice
Hiroshi Yukawa, Hirofumi Noguchi, Koichi Oishi,Soichi Takagi, Michinari Hamaguchi, Nobuyuki Hamajima, and Shuji Hayashi

Cryopreservation In Situ of Cell Monolayers on Collagen Vitrigel Membrane Culture Substrata: Ready-to-Use Preparation of Primary Hepatocytes and ES Cells
Yoshitaka Miyamoto, Shin Enosawa, Tomoyo Takeuchi, and Toshiaki Takezawa

Superagonist CD28 Antibody Preferentially Expanded Foxp3-Expressing nTreg Cells and Prevented Graft-Versus-Host Diseases
Yusuke Kitazawa, Masayuki Fujino, Xiao-Kang Li,Lin Xie, Naotsugu Ichimaru, Masayoshi Okumi, Norio Nonomura,Akira Tsujimura, Yoshitaka Isaka, Hiromitsu Kimura,Thomas Hünig, and Shiro Takahara

Comparative Study of the Cellular Pharmacodynamics of Calcineurin Inhibitors Between Patients With Chronic Renal Failure Awaiting Renal Transplantation and Cirrhosis Patients Awaiting Liver Transplantation
Yu Kihara, Naoto Matsuno, Abuduxukuer Mijiti,Takeshi Nagao, Hironori Takeuchi, Sakae Unezaki, and Toshihiko Hirano

Global Expression Profiles in 1-Hour Biopsy Specimens of Human Kidney Transplantation From Donors After Cardiac Death
Mamoru Kusaka, Yoko Kuroyanagi, Terumi Mori, Kayuri Nagaoka, Hitomi Sasaki, Takahiro Maruyama, Kunihiro Hayakawa, Ryoichi Shiroki, Hiroki Kurahashi, and Kiyotaka Hoshinaga

Clinical Significance of the Cellular Pharmacodynamics of Tacrolimus in Living-Donor Liver Transplantation
Abuduxukuer Mijiti, Naoto Matsuno, Hironori Takeuchi,Sakae Unezaki, Takeshi Nagao, and Toshihiko Hirano

Hepatocytes From Fibrotic Liver Possess High Growth Potential in Vivo
Manabu Nishie, Chise Tateno, Rie Utoh, Toshihiko Kohashi, Norio Masumoto, Naoya Kobayashi, Toshiyuki Itamoto, Noriaki Tanaka, Toshimasa Asahara, and Katsutoshi Yoshizato

Preconditioned Cell Array Optimized for a Three-Dimensional Culture of Hepatocytes
Yoshitaka Miyamoto, Takeshi Ikeya, and Shin Enosawa

Neovascularization Induced Around an Artificial Device Implanted in the Abdomen by the Use of Gelatinized Fibroblast Growth Factor 2
Takeshi Yuasa, Jorge D. Rivas-Carrillo, Nalú Navarro-Alvarez, Alejandro Soto-Gutierrez, Yasuhiro Kubota,Yasuhiko Tabata, Teru Okitsu, Hirofumi Noguchi, Shinichi Matsumoto,Shuhei Nakaji, Noriaki Tanaka, and Naoya Kobayashi

VOLUME 18, NUMBER 4, 2009

Original Contributions

ERas Is Expressed in Primate Embryonic Stem Cells But Not Related to Tumorigenesis
Yujiro Tanaka, Tamako Ikeda, Yukiko Kishi, Shigeo Masuda, Hiroaki Shibata, Kengo Takeuchi, Makoto Komura, Tadashi Iwanaka, Shin-ichi Muramatsu, Yasushi Kondo, Kazutoshi Takahashi, Shinya Yamanaka, and Yutaka Hanazono

Neurotrophism of Bone Marrow Stromal Cells to Embryonic Stem Cells: Noncontact Induction and Transplantation to a Mouse Ischemic Stroke Model
Tao Yang, Kam Sze Tsang, Wai Sang Poon, and Ho Keung Ng

Transplantation of Allogeneic and Xenogeneic Placenta-Derived Cells Reduces Bleomycin-Induced Lung Fibrosis
Anna Cargnoni, Lucia Gibelli, Alessandra Tosini, Patrizia Bonassi Signoroni, Claudia Nassuato, Davide Arienti, Guerino Lombardi, Alberto Albertini, Georg S. Wengler, and Ornella Parolini

DAPI Diffusion After Intravitreal Injection of Mesenchymal Stem Cells in the Injured Retina of Rats
Paula Castanheira, Leonardo Torquetti Torquetti, Débora Rodrigues Soares Magalhãs, Marcio B. Nehemy, and Alfredo M. Goes

A Novel Strategy Incorporated the Power of Mesenchymal Stem Cells to Allografts for Segmental Bone Tissue Engineering
Xiao Hui Zou, Hong Xin Cai, Zi Yin, Xiao Chen, Yang Zi Jiang, Hu Hu, and Hong Wei Ouyang

Bone Regeneration and Neovascularization Processes in a Pellet Culture System for Periosteal Cells
Mari Akiyama and Masaaki Nakamura

Clinical Use of Fructosamine in Islet Transplantation
Thipaporn Tharavanij, Tatiana Froud, Cristiane B. Leitao, David A. Baidal, Charlotte N. Paz-Pabon, Messinger Shari, Pablo Cure, Karina Bernetti, Camillo Ricordi, and Rodolfo Alejandro

Reversible Regulation of Cell Cycle-Related Genes by Epigallocatechin Gallate for Hibernation of Neonatal Human Tarsal Fibroblasts
Jung Yoon Bae, Jun Kanamune, Dong-Wook Han, Kazuaki Matsumura, and Suong-Hyu Hyon

A Simple Breeding Protocol for the Procurement of Accurately Staged Rat Donor Embryos for Neural Transplantation
U. M. Weyrauch, E. M. Torres, A. L. Baird, and S. B. Dunnett

Naive Rat Amnion-Derived Cell Transplantation Improved Left Ventricular Function and Reduced Myocardial Scar of Postinfarcted Heart
Kazuro L. Fujimoto, Toshio Miki, Li J. Liu, Ryotaro Hashizume, Stephen C. Strom, William R. Wagner, Bradley B. Keller, and Kimimasa Tobita


Beijing Declaration of International Association of Neurorestoratology (IANR)

VOLUME 18, NUMBER 3, 2009

Cardiac Stem Cell Therapy: Advances From 2008
Amit N. Patel and Warren Sherman


Early Translation of Adipose-Derived Cell Therapy for Cardiovascular Disease
Ricardo Sanz-Ruiz, Eugenia Fernández-Santos, Marta Domínguez-Muñoa, Radoslaw Parma, Adolfo Villa, Lucía Fernández, Pedro L. Sánchez, and Francisco Fernández-Avilés

Function and Mode of Regulation of Endothelial Major Histocompatibility Complex Class II
Irina Alexander, Elazer R. Edelman, and Heiko Methe

Original Contributions

NF-kB Activity in Endothelial Cells Is Modulated by Cell Substratum Interactions and Influences Chemokine-Mediated Adhesion of Natural Killer Cells
Shmuel Hess, Heiko Methe, Jong-Oh Kim, and Elazer R. Edelman

Evaluation of a Peritoneal-Generated Cardiac Patch in a Rat Model of Heterotopic Heart Transplantation
Gabriel Amir, Liron Miller, Michal Shachar, Micha S. Feinberg, Radka Holbova, Smadar Cohen, and Jonathan Leor

Implantation of a Three-Dimensional Fibroblast Matrix Improves Left Ventricular Function and Blood Flow After Acute Myocardial Infarction
Hoang M. Thai, Elizabeth Juneman, Jordan Lancaster, Tracy Hagerty, Rose Do, Lisa Castellano, Robert Kellar, Stuart Williams, Gulshan Sethi, Monika Schmelz, Mohamed Gaballa, and Steven Goldman

Percutaneous Cell Delivery Into the Heart Using Hydrogels Polymerizing In Situ
Timothy P. Martens, Amandine F. G. Godier, Jonathan J. Parks, Leo Q. Wan, Michael S. Koeckert, George M. Eng, Barry I. Hudson, Warren Sherman, and Gordana Vunjak-Novakovic

Ex Vivo Nanofiber Expansion and Genetic Modification of Human Cord Blood-Derived Progenitor/Stem Cells Enhances Vasculogenesis
Hiranmoy Das, Nasreen Abdulhameed, Matthew Joseph, Ramasamy Sakthivel, Hai-Quan Mao, and Vincent J. Pompili

A Transformed Cell Population Derived From Cultured Mesenchymal Stem Cells Has no Functional Effect After Transplantation Into the Injured Heart
Dario Furlani, Wenzhong Li, Erik Pittermann, Christian Klopsch, Liang Wang, Agnes Knopp, Philipp Jungebluth, Elke Thedinga, Carolin Havenstein, Ingeborg Westien, Murat Ugurlucan, Ren-Ke Li, Nan Ma, and Gustav Steinhoff

Myoblast Transfer in Ischemic Heart Failure: Effects on Rhythm Stability
Warren Sherman, Kun-Lun He, Geng-Hua Yi, Jie Wang, Jack Harvey, Myung J. Lee, Howard Haimes, Paul Lee, Emma Miranda, Sunil Kanwal, and Daniel Burkhoff

Autologous Bone-Marrow Mononuclear Cell Transplantation After Acute Myocardial Infarction: Comparison of Two Delivery Techniques
Suzana A. Silva, André L. S. Sousa, Andrea F. Haddad, Jader C. Azevedo, Vinicio E. Soares, Cíntia M. Peixoto, Ana J. S. Soares, Aurora F. C. Issa, Luis Renato V. Felipe, Rodrigo V. C. Branco, João A. Addad, Rodrigo C. Moreira, Fabio A. A. Tuche, Cláudio T. Mesquita, Cristina C. O. Drumond, Amarino O. Junior, Carlos E. Rochitte, José H. M. Luz, Arnaldo Rabischoffisky, Fernanda B. Nogueira, Rosana B. C. Vieira, Hamilton S. Junior,  Radovan Borojevic, and Hans F. R. Dohmann

Intramyocardial Injection of Autologous Platelet-Rich Plasma Combined With Transmyocardial Revascularization
K. E. Wehberg, G. Answini, D. Wood, J. Todd, J. Julian, N. Ogburn, and K. B. Allen

Two-Dimensional Speckle Tracking Strain Analysis for Efficacy Assessment of Myocardial Cell Therapy
Boris A. Nasseri, Marian Kukucka, Michael Dandel, Christoph Knosalla, Yeong-Hoon Choi, Wolfram Ebell, Roland Hetzer, and Christof Stamm

Autologous Bone Marrow Cell Transplantation Increases Leg Perfusion and Reduces Amputations in Patients With Advanced Critical Limb Ischemia Due to Peripheral Artery Disease
Berthold Amann, Claas Luedemann, Richard Ratei, and J. André Schmidt-Lucke

VOLUME 18, NUMBER 2, 2009


Amnion: A Potent Graft Source for Cell Therapy in Stroke
Seong Jin Yu, Maddalena Soncini, Yuji Kaneko, David C. Hess, Ornella Parolini, and Cesar V. Borlongan

Original Contributions

Microtransplantation of Dopaminergic Cell Suspensions: Further Characterization and Optimization of Grafting Parameters
Guido Nikkhah, Christoph Rosenthal, Gero Falkenstein, Alexandra Roedter, Anna Papazoglou, and Almuth Brandis

Effective Cryopreservation of Neural Stem or Progenitor Cells Without Serum or Proteins by Vitrification
L. L. Kuleshova, F. C. K. Tan, R. Magalhães, S. S. Gouk, K. H. Lee, and G. S. Dawe

Delivery of Adipose-Derived Precursor Cells for Peripheral Nerve Repair
Lizzie Y. Santiago, Julio Clavijo-Alvarez, Candace Brayfield, J. Peter Rubin, and Kacey G. Marra

Cartilage Regeneration of Adipose-Derived Stem Cells in a Hybrid Scaffold From Fibrin-Modified PLGA
Yiyong Wei, Hunyu Hu, Haiqiang Wang, Yinsong Wu, Lianfu Deng, and Jin Qi

Assessments of Proliferation Capacity and Viability of New Zealand Rabbit Peripheral Blood Endothelial Progenitor Cells Labeled With Superparamagnetic Particles
Xiao-Li Mai, Zhan-Long Ma, Jun-Hui Sun, Sheng-Hong Ju, Ming Ma, and Gao-Jun Teng

Generation of Hepatocyte-Like Cells From In Vitro Transdifferentiated Human Fetal Pancreas
Suchitra Sumitran-Holgersson, Greg Nowak, Shifaan Thowfeequ, Setara Begum, Meghnad Joshi, Marie Jaksch, Anders Kjaeldgaard, Carl Jorns, Bo-Göran Ericzon, and David Tosh

Effect of Micro- and Macroencapsulation on Oxygen Consumption by Pancreatic Islets
Roberta Cornolti, Marina Figliuzzi, and Andrea Remuzzi

Brief Communication

Collagenase Isoforms for Pancreas Digestion
Federico Bertuzzi, Silvia Cainarca, Simona Marzorati, Angela Bachi, Barbara Antonioli, Rita Nano, Roberto Verzaro, and Camillo Ricordi

Abstracts for the 16th Annual Meeting of the American Society for Neural Therapy and Repair

VOLUME 18, NUMBER 1, 2009


Extracellular Matrix in Pancreatic Islets: Relevance to Scaffold Design and Transplantation
John C. Stendahl, Dixon B. Kaufman, and Samuel I. Stupp

Original Contributions

Toward Improving Human Islet Isolation From Younger Donors: Rescue Purification Is Efficient for Trapped Islets
A. Miki, C. Ricordi, Messinger, T. Yamamoto, A. Mita, S. Barker, R. Haetter, A. Khan, R. Alejandro, and H. Ichii

Beneficial Role of Pancreatic Microenvironment for Angiogenesis in Transplanted Pancreatic Islets
Joey Lau, Caroline Kampf, Göran Mattsson, Daniel Nyqvist, Martin Köhler, Per-Olof Berggren, and Per-Ola Carlsson

The Effect of Composite Pig Islet-Human Endothelial Cell Grafts on the Instant Blood-Mediated Inflammatory Reaction
Hyoung-Il Kim, Jae Eun Yu, Song Yi Lee, A. Young Sul, Min Seok Jang, M. A. Rashid, Sang Gyu Park, Sang Jun Kim, Chung-Gyu Park, Jae Hyeon Kim, and Kyong Soo Park

Cotransplantation of Mouse Embryonic Stem Cells and Bone Marrow Stromal Cells Following Spinal Cord Injury Suppresses Tumor Development
Ryosuke Matsuda, Masahide Yoshikawa, Hajime Kimura, Yukiteru Ouji, Hiroyuki Nakase, Fumihiko Nishimura, Jun-ichi Nonaka, Hayato Toriumi, Shuichi Yamada, Mariko Nishiofuku, Kei Moriya, Shigeaki Ishizaka, Mitsutoshi Nakamura, and Toshisuke Sakaki

Retentive Multipotency of Adult Dorsal Root Ganglia Stem Cells
Rabindra P. Singh, Ying-Hua Cheng, Paul Nelson, and Feng C. Zhou

Noninvasive Imaging of Liver Repopulation Following Hepatocyte Transplantation
Sarah Koenig, Petra Krause, Ali Seif Amir Hosseini, Christian Dullin, Margret Rave-Fraenk, Sarah Kimmina, Andrew Lee Entwistle, Robert Michael Hermann, Clemens Friedrich Hess, Heinz Becker, and Hans Christiansen

Wheat Proteins Enhance Stability and Function of Adhesion Molecules in Cryopreserved Hepatocytes
Mélanie Grondin, Francine Hamel, Diana A. Averill-Bates, and Fathey Sarhan

Suppression of Carbon Tetrachloride-Induced Liver Fibrosis by Transplantation of a Clonal Mesenchymal Stem Cell Line Derived From Rat Bone Marrow
Marhaen Hardjo, Masahiro Miyazaki, Masakiyo Sakaguchi, Takuro Masaka, Sukaeni Ibrahim, Ken Kataoka, and Nam-ho Huh

Improved Survival of Fulminant Liver Failure by Transplantation of Microencapsulated Cryopreserved Porcine Hepatocytes in Mice
Jie Mei, Antonino Sgroi, Gang Mai, Reto Baertschiger, Carmen Gonelle-Gispert, Véronique Serre-Beinier, Philippe Morel, and Leo H. Bühler