ognizant Communication Corporation





About the Conference

Invited Speaker Abstracts

Abstracts From Conference Participating Scientists

Volume 15 Subject and Author Index


Laboratory Research

Resveratrol and Propolis Extract: An Insight Into the Morphological and Molecular Changes Induced in DU145 Cells
Christian Scifo, Angela Milasi, Andrea Guarnera, Fulvia Sinatra, and Marcella Renis

Adenylate Cyclase Toxin From Bordetella pertussis Enhances Cisplatin-Induced Apoptosis to Lung Cancer Cells In Vitro
David Johansson, Per Bergström, Roger Henriksson, Kjell Grankvist, Anders Johansson, and Parviz Behnam-Motlagh

Does Survival Increase in Metastatic Breast Cancer With Recently Available Anticancer Drugs?
C. Abrial, M. Leheurteur, A. Cabrespine, M. A. Mouret-Reynier, X. Durando, J. P. Ferriere, F. Kwiatkowski, F. Penault-Llorca, H. Cure, and P. Chollet

Clinical Research

Immunohistochemical Detection of Apoptotic Markers in Gastric Cancer
Laura Smith, Helen K. Berrieman, Sara L. O'Kane, Anne Campbell, Anthony Maraveyas, and Lynn Cawkwell

VEGF Expression in the Colorectal Adenoma-Carcinoma Sequence
Loukas Kaklamanis, Miltiades Trichas, Kyriakos, Amarantidis, Nikol Spathari, Anastasia Micheli, Anastasios Karayiannakis, Ekaterini Chatzaki, Vasilis Georgoulias, and Stelios Kakolyris


Laboratory Research

Overexpression of Extracellular Superoxide Dismutase (EC-SOD) in Mouse Skin Plays a Protective Role in DMBA/TPA-Induced Tumor Formation
Sung-Hyun Kim, Myoung-Ok Kim, Peng Gao, Cheng-A Youm, Hae-ryoung Park, Sang-Ryeul Lee, Kil-Soo Kim, Jun-Gyo Suh, Hoon-Taek Lee, Byung-Ju Park, Zae-Young Ryoo, and Tae-Hoon Lee

Antitumor Effects of Angiostatin K1-3 and Endostatin Genes Coadministered by the Hydrodynamics-Based Transfection Method
Keun Sik Kim and Young Serk Park

A Comparison of the Ability of DMXAA and Xanthenone Analogues to Activate NF-kB in Murine and Human Cell Lines
See-Tarn Woon, Charu B. Reddy, Catherine J. Drummond, Mary Ann Schooltink, Bruce C. Baguley, Claudine Kieda, and Lai-Ming Ching

CD9 Overexpression Suppressed the Liver Metastasis and Malignant Ascites via Inhibition of Proliferation and Motility of Small-Cell Lung Cancer Cells in NK Cell-Depleted SCID Mice
Rui Zheng, Seiji Yano, Helong Zhang, Emiko Nakataki, Isao Tachibana, Ichiro Kawase, Seiji Hayashi, and Saburo Sone

Decoy Molecules Based on PNA-DNA Chimeras and Targeting Sp1 Transcription Factors Inhibit the Activity of Urokinase-Type Plasminogen Activator Receptor (uPAR) Promoter
Monica Borgatti, Douglas D. Boyd, Ilaria Lampronti, Nicoletta Bianchi, Enrica Fabbri, Michele Saviano, Alessandra Romanelli, Carlo Pedone, and Roberto Gambari

Irinotecan/5-Fluorouracil Combination Induces Alterations in Mitochondrial Membrane Potential and Caspases on Colon Cancer Cell Lines
Ivana Grivicich, Andréa Regner, Adriana B. da Rocha, Luciano B. Grass, Pedro A. G. Alves, Guilherme B. Kayser, Gilberto Schwartsmann, and João A. Henriques

Clinical Research

There Is No Evidence That the SDHB Gene Is Involved in Neuroblastoma Development
Elena Grau, Silvestre Oltra, Carmen Orellana, Miguel Hernández-Martí, Victoria Castel, and Francisco Martínez

Treatment With Stem Cell Differentiation Stage Factors of Intermediate-Advanced Hepatocellular Carcinoma: An Open Randomized Clinical Trial
Tito Livraghi, Franca Meloni, Alberto Frosi, Sergio Lazzaroni, Mariano Bizzarri, Luigi Frati, and Pier Mario Biava



Do Negative Feedback Oscillations Drive Variations in the Length of the Tumor Cell Division Cycle?
Bruce C. Baguley and Elaine Marshall

Laboratory Research

Transient Absorption Spectra and Kinetics of Folic Acid (Vitamin B11) and Some Kinetic Data of Folinic Acid and Methotrexate
Nikola Getoff

Effect of Glibenclamide on N-Nitroso-N-Methylurea-Induced Mammary Tumors in Diabetic and Nondiabetic Rats
Claudia Cocca, Gabriela Martín, Mariel Núñez, Alicia Gutiérrez, Graciela Cricco, Nora Mohamad, Vanina Medina, Máximo Croci, Ernesto Crescenti, Elena Rivera, and Rosa Bergoc

The Antineoplastic Efficacy of the Prodrug CloretazineTM Is Produced by the Synergistic Interaction of Carbamoylating and Alkylating Products of its Activation
Raymond P. Baumann, Helen A. Seow, Krishnamurthy Shyam, Philip G. Penketh, and Alan C. Sartorelli

Inhibition of Protein Kinase CKII Activity by Euchrestaflavanone B Purified From Cudrania tricuspidata
Soon-Hee Kim, Soo-Hyun Yoon, Byong Won Lee, Li Hun Park, Young Ho Kim, and Young-Seuk Bae


Laboratory Research

Gene Therapeutic Exploration: Retrovirus-Mediated Soluble Vascular Endothelial Growth Factor Receptor-2 (sFLK-1) Inhibits the Tumorigenicity of S180, MCF-7, and B16 Cells In Vivo
Baijun Kou, Yulin Li, Yingai Shi, Jianxin Xia, Xinrui Wang, and Shan Wu

Bcl-2 as Prognostic Factor in Head and Neck Squamous Cell Carcinoma
Lorenzo Lo Muzio, Silvia Falaschini, Antonio Farina, Corrado Rubini, Furio Pezzetti, Guiseppina Campisi, Gaetano De Rosa, Mario Capogreco, and Francesco Carinci

Hypomethylation of the XIST Gene Promoter in Prostate Cancer
Thilo Laner, Wolfgang A. Schulz, Rainer Engers, Mirko Müller, and Andrea R. Florl

A Bisanthracycline (WP631) Represses uPAR Gene Expression and Cell Migration of RKO Colon Cancer Cells by Interfering With Transcription Factor Binding to a Chromatin-Accessible -148/-124 Promoter Region
Rajesh R. Nair, Heng Wang, Md. S. Jamaluddin, Izabella Fokt, Waldemar Priebe, and Douglas D. Boyd

Clinical Research

The Use of Complementary and Alternative Therapies by Patients With Cancer
Afaf Girgis, Jon Adams, and David Sibbritt


Laboratory Research

Activity of Bacteriophages in Murine Tumor Models Depends on the Route of Phage Administration
Krystyna Dabrowska, Adam Opolski, Joanna Wietrzyk, Dmitry Nevozhay, Katarzyna Szczaurska, Kinga Switala-Jelen, Janusz Boratynski, and Andrzej Górski

Inhibition of Cellular Adhesion in Human Umbilical Vein Endothelial Cells by NK-kB Inhibitor DHMEQ Under Flow
Osamu Ohno, Yutaka Shima, Yasuo Ikeda, Kumi Sakurai, Kiyoaki Watanabe, Yohko Kawai, and Kazuo Umezawa

Formaldehyde-Releasing Prodrugs in Combination With Adriamycin Can Overcome Cellular Drug Resistance
Suzanne M. Cutts, Abraham Nudelman, Vinochani Pillay, Damian M. S. Spencer, Inesa Levovich, Ada Rephaeli, and Don R. Phillips

Phosphor/Sulphur Ration: An Indicator of Maligant Uterus Change
Kálmán Patai, László Dévényi, Márta Hubay, Sándor Csömör, and Romána Zelkó

Interaction of Strong DNA-Intercalating Bioreductive Compounds With Topoisomerases I and II
H. S. Rosenzweig, M. V. Papadopoulou, and W. D. Bloomer

Clinical Research

Analysis of Inter-(Simple Sequence Repeat) PCR Products From Human Colorectal Cancers
Neng Chen, Daniel L. Stoler, Smitha S. Dutt, Gerald P. Jahreis, Miguel A. Rodriguez-Bigas, Nicholas J. Petrelli, and Garth R. Anderson


Laboratory Research

Activation of Cyclin D1 by Estradiol and Spermine in MCF-7 Breast Cancer Cells: A Mechanism Involving the p38 MAP Kinase and Phosphorylation of ATF-2
Joan s. Lewis, Veena Vijayanathan, T. J. Thomas, Richard G. Pestell, Chris Albanese, Michael A. Gallo and Thresia Thomas

In Vitro Antitumor Structure-Activity Relationships of threo/trans/threo/trans/erythro bis-Tetrahydrofuranic Acetogenins: Correlations With Their Inhibition of Mitochondrial Complex I
José R. Tormo, Nuria DePedro, Inmaculada Royo, Isabel Barrachina, M. Carmen Zafra-Polo, Cristina Cuadrillero, Pilar Hernández, Diego Cortes, and Fernando Paláez

Mutant IkBa Suppresses Hypoxia-Induced VEGF Expression Throught Downregulation of HIF-1a and COX-2 in Human Glioma Cells
Yoshihira Kimba, Tatsuya Abe, Jian Liang Wu, Ryo Inoue, Minoru Fukiki, Kimitoshi Kohno, and Hidenori Kobayashi

Influence of p53 Status on the HSV-Tk/GCV-Induced Bystander Effect in a Panel of Human Ovarian Carcinoma Cell Lines
Ingrid J. van Dillen, Nanno H. Mulder, Wim J. Sluiter, Coby Meijer, Steven de Jone, Jadranka Loncarek, Marc Mesnil, Erik F. J. de Vries, Willem Vaalburg, and Geke A. P. Hospers

Caspases-Dependent Cleavage of Mitotic Checkpoint Proteins in Response to Microtubule Inhibitor
Kwan-Hyuck Baek, Hyun-Jin Shin, Sook-Jung Jeong, Joong-Won Park, Frank McKeon, Chang-Woo Lee, and Chang-Min Kim

Tumor Transition Zones: A Putative New Morphological and Functional Hallmark of Tumor Aggressiveness
Oscar D. Bustuoabad, Raúl A. Ruggiero, Pedro di Gianni, M. Gabriela Lombardi, Carolina Belli, Gabriela V. Camerano, Braciela Dran, Carolina Schere-Levy, Héctor Costa, Martín A. Isturiz, Marian Narvaitz, Nico van Rooijen, Victoria de los A. Bustuoabad, and Roberto P. Meiss


Laboratory Research

Antineoplastic Agents 540. The Indian Gynandropis gynandra (Capparidaceae)
George R. Pettit, Yanhui Meng, Delbert L. Herald, Andrew M. Stevens, Robin K. Pettit, and Dennis L. Doubek

Expression of Estrogen Receptor a Gene in Breast Cancer Cells Treated With Transcription Factor Decoy Is Modulated by Bangladeshi Natural Plant Extracts
Elizabeth Lambertini, Ilaria Lampronti, Letizia Penolazzi, Mahmud Tareq Hassan Khan, Arjumand Ather, Gianluca Giorgi, Roberto Gambari, and Roberta Piva

Pentoxifylline Inhibits Agonist-Induced Vasoconstriction in Vascular Smooth Muscle and Spontaneous Peristalsis in Isolated Ileum
Mark W. Ruddock and David G. Hirst

Synthesis and Antimelanoma Activity of Sterically Congested Tertiary Amide Analogues of N-Acetyl-4-S-cysteaminylphenol
Jillian Ferguson, Paul M. Rogers, Lloyd R. Kelland, and David J. Robbins

Antitumor Polycyclic Acridines. Part 16. Triplex DNA as a Target for DNA-Binding Polycyclic Acridine Derivatives
Sotiris Missailidis, Chetna Modi, Valentina Trapani, Charles A Laughton, and Malcolm F. G. Stevens

Clinical Research

Retreatment of Lung Adenocarcinoma Patients With Gefitinib Who Had Experienced Favorable Results From Their Initial Treatment With This Selective Epidermal Growth Factor Receptor Inhibitor: A Report of Three Cases
Seiji Yano, Emiko Nakataki, Shinsaku Ohtsuka, Mami Inayama, Hideki Tomimoto, Nobutaka Edakuni, Soji Kakiuchi, Naoki Nishikubo, Hiroaki Muguruma, and Saburo Sone


Laboratory Research

Zoledronic Acid Mediates Ras-Independent Growth Inhibition of Prostate Cancer Cells
Masaki Nogawa, Takeshi Yuasa, Shinya Kimura, Junya Kuroda, Hidekazu Segawa, Kiyoshi Sato, Asumi Yokota, Mitsutera Koizumi, and Taira Maekawa

Antineoplastic Agents 470. Absolute Configuration of the Marine Sponge Bromopyrrole Agelastatin A
George R. Pettit, Sylvie Ducki, Delbert L. Herald, Dennis L. Doubek, Jean M. Schmidt, and Jean-Charles Chapuis

Mechanisms of Action of Differentiation Inducers: Detection of Inducer Binding Protein(s) in Murine Erythroleukemia Cells
Ioannis S. Pappas, John D. Lambris, Ioannis S. Vizirianakis, Michael S. Winters, and Asterios S. Tsiftsoglou

In Vitro Study of CI-994, a Histone Deacetylase Inhibitor, in Non-Small Cell Lung Cancer Cell Lines
Maura Loprevite, Marcello Tiseo, Francesco Grossi, Tindaro Scolaro, Claudia Semino, Alessandra Pandolfi, Roberto Favoni, and Andrea Ardizzoni

Frequent Overexpression of STK15/Aurora-A/BTAK and Chromosomal Instability in Tumorigenic Cell Cultures Derived From Human Ovarian Cancer
Wei Hu, John J. Kavanagh, Michael Deaver, Dennis A. Johnston, Ralph S. Freedman, Claire F. Verschraegen, and Subrata Sen