ognizant Communication Corporation

ONCOLOGY RESEARCH
AN INTERNATIONAL JOURNAL
INCORPORATING ANTI-CANCER DRUG DESIGN

TABLES OF CONTENTS
VOLUME 16

VOLUME 16, NUMBER 12

Laboratory Research

Cellular Studies of MrDb (DDX18)
Sandy Dubaele and Patrick Chène

Antisense Experiments Demonstrate an Exon 4 Minus Splice Variant mRNA as the Basis for Expression of tNOX, a Cancer-Specific Cell Surface Protein
Xiaoyu Tang, D. James Morré, and Dorothy M. Morré

Metabolites of the Radiosensitizer Nicotinamide Are Unlikely to Contribute to the Degree of Emesis Observed With the Parent Drug
Mark W. Ruddock and David G. Hirst

Adenosine Modulates Cell Growth in the Human Breast Cancer Cells Via Adenosine Receptors
Mojtaba Panjehpour and Fatemeh Karami-Tehrani

Clinical Research

Association of CYP1A1 Polymorphisms With Breast Cancer in North Indian Women
Neetu Singh, Amit Kumar Mitra, Vivek Kumar Garg, Amit Agarwal, Mandira Sharma, Rashmi Chaturvedi, and Srikanta Kumar Rath

Volume 16 Subject and Author Index


VOLUME 16, NUMBER 11

Laboratory Research

The Proteomic Analysis of Cisplatin Resistance in Breast Cancer Cells
Laura Smith, Kevin J. Welham, Mark B. Watson, Philip J. Drew, Michael J. Lind, and Lynn Cawkwell

Actin-Sequestering Protein, Thymosin-Beta-4 (TB4), Inhibits Caspase-3 Activation in Paclitaxel-Induced Tumor Cell Death
Eun-Yi Moon, Ji-Hee Song, and Kyu-Hwan Yang

The Effect of Combined Treatment on Head and Neck Human Cancer Cell Lines With Novel Analogs of Calcitriol and Cytostatics
Joanna Wietrzyk, Magdalena Milczarek, and Andrzej Kutner

Alterations Found in p16/Rb/Cyclin D1 Pathway in the Dysplastic and Malignant Cervical Epithelium
N. Vijayalakshmi, G. Selvaluxmi, U. Majhi, and T. Rajkumar

Clinical Research

Analysis of Gene Expression Profiles Reveals Novel Correlations With the Clinical Course of Colorectal Cancer
Duccio Cavalieri, Piero Dolara, Enrico Mini, Cristina Luceri, Cinzia Castagnini, Simona Toti, Karolina Maciag, Carlotta De Filippo, Stefania Nobili, Maria Morganti, Cristina Napoli, Giulia Tonini, Michela Baccini, Annibale  Biggeri, Francesco Tonelli, Rosa Valanzano, Claudio Orlando, Stefania Gelmini, Fabio Cianchi, Luca Messerini, and Lucio Luzzatto


VOLUME 16, NUMBER 10

Laboratory Research

Valproic Acid Increases the In Vitro Effects of Nitrosureas on Human Glioma Cell Lines
Emilio Ciusani, Marco Balzarotti, Chiara Calatozzolo, Ugo de Grazia, Amerigo Boiardi, Andrea Salmaggi, and Danilo Croci

Expression of the Human MTA1 Gene in Breast Cell Lines and in Breast Cancer Tissues
Dan Tong, Georg Heinze, Michael Schremmer, Eva Schuster, Klaus Czerwenka, Sepp Leodolter, and Robert Zeillinger

Evaluation of Adenoviral Oncolytic Effect on Glioma Spheroids by 18F-DG Positron-Emission Tomography
S. Idema, A. A. Geldof, C. M. F. Dirven, M. van der Jagt, W. R. Gerritsen, W. P. Vandertop, and M. L. M. Lamfers

Cisplatin-Induced Senescence and Growth Inhibition in Human Non-Small Cell Lung Cancer Cells With Ectopic Transfer of p16INK4a
Kang Fang, Chien-Chih Chiu, Chin-Hsiao Li, Yung-ta Chang, and Hwei-tein Hwang

Clinical Research

Short-Term Gefitinib Treatment Brought About a Long-Term Regression of Bronchioloalveolar Carcinoma Without EGFR Gene Alterations: A Case Report
Takashi Kijima, Mayumi Suzuki, Kayo Ueda, Seigo Minami, Yoshito Takeda, Sho Goya, Hiroto Matsuoka, Toru Kumagai, Mitsuhiro Yoshida, Tadashi Osaki, Isao Tachibana, Soichiro Yokota, and Ichiro Kawase


VOLUME 16, NUMBER 9

Laboratory Research

Functional Evidence for a Nasopharyngeal Carcinoma-Related Gene BCAT1 Located at 12p12
Wen Zhou, Xiangling Feng, Hong Li, Lei Wang, Hui Li, Bin Zhu, Hejun Zhang, Kaitai Yao, Caiping Ren

Antitumor Activity of Mannan-Methotrexate Conjugate In Vitro and In Vivo
Renata Budzynska, Dmitry Nevozhay, Urszula Kanska, Monika Jagiello, Adam Opolski, Joanna Wietrzyk, and Janusz Boratynski

The Role of GSTM1 and GSTT1 Polymorphisms in Head and Neck Cancer Risk
Halit Sinan Suzen, Gulçin Guvenc, Mehmet Turanli, Ela Comert, Yalçin Duydu, and Atilla Elhan

Loss of Hugl-1 Expression Associates With Lymph Node Metastasis in Endometrial Cancer
Tetsushi Tsuruga, Shunsuke Nakagawa, Michiko Watanabe, Shin Takizawa, Yoko Matsumoto, Kazunori Nagasaka, Kenbun Sone, Haruko Hiraike, Yuichiro Miyamoto, Osamu Hiraike, Takeo Minaguchi, Katsutoshi Oda, Toshiharu Yasugi, Tetsu Yano, and Yuji Taketani

CYP1A1 Msp1 T/C Polymorphism in Esophageal Cancer: No Association and Risk Modulation
Meenu Jain, Shaleen Kumar, Uday C. Ghoshal, and Balraj Mittal

Clinical Research

Serum Levels of VEGF-C, VEGF-D, and sVEGF-R2 in Patients With Lung Cancer During Chemotherapy
Wojciech Naumnik, Tomasz Izycki, Ewa Swidzinska, Maria Ossolinska, and Elzbieta Chyczewska


VOLUME 16, NUMBER 8

Laboratory Research

TAT Peptide-Modified Liposomes Provide Enhanced Gene Delivery to Intracranial Human Brain Tumor Xenografts in Nude Mice
Bhawna Gupta, Tatiana S. Levchenko, and Vladimir P. Torchilin

Increased Preclinical Efficacy of Irinotecan and Floxuridine Coencapsulated Inside Liposomes Is Associated With Tumor Delivery of Synergistic Drug Ratios
Troy O. Harasym, Paul G. Tardi, Natashia L. Harasym, Pierrot Harvie, Sharon A. Johnstone, and Lawrence D. Mayer

Clinical Research

IL-2, TNF-a, and Leptin: Local Versus Systemic Concentrations in NSCLC Patients
Giovanna E. Carpagnano, Antonio Spanevello, Claudia Curci, Francesco Salerno, Grazia P. Palladino, Onofrio Resta, Giuseppe Di Gioia, Francesco Carpagnano, and Maria P. Foschino Barbaro

Prenatal and Perinatal Risk Factors and Testicular Cancer: A Hospital-Based Case-Control Study
Gabe S. Sonke, Shine Chang, Sara S. Strom, Anne M. Sweeney, J. Fred Annegers, and Alice J. Sigurdson

Radiation-Induced Antitumor Properties of Vitamin B5 (Pantothenic Acid) and its Effects on Mitomycin C Activity: Experiments In Vitro
Heike Schittl and Nikola Getoff

Expression of MDR1 in Epithelial Ovarian Cancer and its Association With Disease Progression
Lingeng Lu, Dionyssios Katsaros, Andrew Wiley, Irene A. Rigault de la Longrais, Manuela Puopolo, and Herbert Yu


VOLUME 16, NUMBER 7

Laboratory Research

ECTO-NOX Target for the Anticancer Isoflavene Phenoxodiol
D. James Morré, P.-J. Chueh, Kader Yagiz, Andrew Balicki, Chinpal Kim, and Dorothy M. Morré

Antitumor Effects of Hydroxycamptothecin-Loaded Poly[ethylene glycol]-poly[g-benzyl-L-glutamate] Micelles Against Oral Squamous Cell Carcinoma
Xue-Qiang Ding, Dan Chen, An-Xun Wang, Su Li, Yu Chen, and Ji Wang

DMBA/TPA-Induced Tumor Formation Is Aggravated in Human Papillomavirus Type 16 E6/E7 Transgenic Mouse Skin
Myoung Ok Kim, Sung Hyun Kim, Mi Jung Shin, Dong Hoon Yu, Bong Soo Kim, Kyu Tae Chang, Sanggyu Lee, Yong Bok Park, Tae-Hoon Lee, and Zae Young Ryoo

Clinical Research

Relationship Between the Loss of Heterozygosity and Tobacco Smoking in Pulmonary Adenocarcinoma
Tomofumi Yohena, Ichiro Yoshino, Tomoyoshi Takenaka, Taro Ohba, Hidenori Kouso, Atsushi Osoegawa, Motoharu Hamatake, Shinya Oda, Yukio Kuniyoshi, and Yoshihiko Maehara

Combination Therapy of Personalized Peptide Vaccination and Low-Dose Estramustine Phosphate for Metastatic Hormone Refractory Prostate Cancer Patients: An Analysis of Prognostic Factors in the Treatment
Masanori Noguchi, Takashi Mine, Akira Yamada, Yayoi Obata, Kazumi Yoshida, Junko Mizoguchi, Mamoru Harada, Shigetaka Suekane, Kyogo Itoh, and Kei Matsuoka
 



VOLUME 16, NUMBER 6

Laboratory Research

Ineffectiveness of American Ginseng in the Prevention of Dimethylbenzanthracene-Induced Mammary Tumors in Mice
Gregory T. Wurz, Cristina Marchisano-Karpman, and Michael W. DeGregorio

Genetic and Epigenetic Alterations of LTF at 3p21.3 in Nasopharyngeal Carcinoma
Hong-Mei Yi, Hui Li, Dan Peng, He-Jun Zhang, Lei Wang, Ming Zhao, kai-Tai Yao, and Cai-Ping Ren

Clinical Research

The Expression of Bcl-2 Family Proteins and Spontaneous Apoptosis in Laryngeal Carcinomas
George C. Chen, Alexander C. Vlantis, Ernest C. W. Chak, Han Ching Liu, Michael C. F. Tong, and Charles A. van Hasselt

A Dose Escalation Study of Docetaxel Plus Capecitabine in Combination With Gemcitabine in Patients With Advanced Solid Tumors
K. Amarantidis, K. Houhouli, K. Papatheodorou, A. Miloussis, D. Matthaios, E. Chatzaki, N. Lyrantzopoulos, A. Tsaroucha, A. Tentes, and S. Kakolyris

Expression of NEU3 (Plasma Membrane-Associated Sialidase) in Clear Cell Adenocarcinoma of the Ovary: Its Relationship With T Factor of pTNM Classification
Hiroyuki Nomura, Yutaka Tamada, Taeko Miyagi, Atsushi Suzuki, Momoyo Taira, Nao Suzuki, Nobuyuki Susumu, Tatsuro Irimura, and Daisuke Aoki



VOLUME 16, NUMBER 5

Laboratory Research

In Vivo Treatment of Melanoma (B16F10) With a Homeopathic Agent and With a Cytokine (IFN-a)
Fernando Pascual-Carpe, Vicente Vicente-Ortega, Matilde Campos-Aranda, and Josefa Yañez-Gascón

Aberrant Expression of HOX Genes in Oral Dysplasia and Squamous Cell Carcinoma Tissues
Nur Mohammad Monsur Hassan, Jun-ichi Hamada, Taichi Murai, Akihusa Seino, Yoko Takahashi, Mitsuhiro Tada, Xiuru Zhang, Haruhiko Kashiwazaki, Yutaka Yamazaki, Nobuo Inoue, and Tetsuya Moriuchi

Role of Intercellular Communications in Breast Cancer Multicellular Tumor Spheroids After Chemotherapy
G. Oktem, A. Bilir, S. Ayla, A. Yavasoglu, G. Goksel, G. Saydam, and A. Uysal

Restored Expression of the MYO18B Gene Suppresses Orthotopic Growth and the Production of Bloody Pleural Effusion by Human Malignant Pleural Mesothelioma Cells in SCID Mice
Nobutaka Edakuni, Kenji Ikuta, Seiji Yano, Emiko Nakataki, Hiroaki Muguruma, Hisanori Uehara, Masachika Tani, Jun Yokota, Hisamichi Aizawa, and Saburo Sone

Brief Communication

In Vitro Study of Low Molecular Weight Heparin Effect on Cell Growth and Cell Invasion in Primary Cell Cultures of High-Grade Gliomas
Marco Balzarotti, Federica Fontana, Carlo Marras, Amerigo Boiardi, Danilo Croci, Emilio Ciusani, and Andrea Salmaggi



VOLUME 16, NUMBER 4

Laboratory Research

Black Tea Polyphenols Protect Against 7,12-Dimethylbenz[a]anthracene-Induced Hamster Buccal Pouch Carcinogenesis
P. Vidjaya Letchoumy, K. V. P. Chandra Mohan, R. Kumaraguruparan, Y. Hara, and S. Nagini

Phosphorylation of ErbB4 on Tyrosine 1056 Is Critical for ErbB4 Coupling to Inhibition of Colony Formation by Human Mammary Cell Lines
Sarah E. Pitfield, Ianthe Bryant, Desi J. Penington, Gar Park, and David J. Riese II

Chemotherapy Influences Inducible Nitric Oxide Synthase (iNOS) and Endothelial Nitric Oxide Synthase (eNOS) Activity on 3D Breast Cancer Cell Line
G. Öktem, A. Bilir, N. Selvi, M. E. Yurtseven, S. Vatansever, U. Ates, A. Uysal, and S. B. Omay

Clinical Research

Association of Promoter Hypermethylation of the RASSF1A Gene With Prognostic Parameters in Endometrial Cancer
Hoenil Jo, Jae Weon Kim, Gyeong Hoon Kang, Noh-Hyun Park, Yong-Sang Song, Soon-Beom Kang, and Hyo-Pyo Lee



VOLUME 16, NUMBER 3

Laboratory Research

In Vitro and In Vivo Evaluation of Two Rational-Designed Nonpeptidic Farnesyltransferase Inhibitors on HT29 Human Colon Cancer Cell Lines
Nicolas Wlodarczyk, Pauline Gilleron, Régis Millet, Raymond Houssin, Jean-François Goossens, Amélie Lemoine, Nicole Pommery, Ming X. Wei, and Jean Pierre Hénichart

Pu-erh Tea Supplementation Suppresses Fatty Acid Synthase Expression in the Rat Liver Through Downregulating Akt and JNK Signalings as Demonstrated in Human Hepatoma HepG2 Cells
Chun-Te Chiang, Meng-Shih Weng, Shoei-Yn Lin-Shiau, Kuan-Li Kuo, Yao-Jen Tsai, and Jen-Kun Lin

The Effect of an Estrone D-Lactam Steroid Ester Derivative on Breast Cancer Cells and Its Predicted Binding Interactions With the Ligand Binding Domain of Estrogen Receptor-a
Michael Kontos, Marilena Nikolopoulou, Dimitrios T. P. Trafalis, George D. Geromichalos, Catherine Koukoulitsa, Charalambos Camoutsis, Elias Bastounis, and Panayiotis Karamanakos

Molecular Characterization of Established Human Colon Carcinoma Cell Lines (HCT-8) Made Resistant to 5-Fluorouracil by Different Selection Schedules
Alessio Tempestini, Barbara Caciagli, Maria Morganti, Ewa Witort, Stefania Nobili, Laura Papucci, Nicola Schiavone, Martino Donnini, Ida Landini, Andrea Lapucci, Federico Perna, Matteo Lulli, Teresita Mazzei, Alberto Sobrero, Enrico Mini, and Sergio Capaccioli

In Vitro Inhibition of Promyelocytic Leukemia/Retinoic Acid Receptor-a (PML/RARa) Expression and Leukemogenic Activity by DNA/LNA Chimeric Antisense Oligos
Sara Caprodossi, Luca Galluzzi, Simona Biagetti, Giulia Della Chiara, Pier Giuseppe Pelicci, Mauro Magnani, and Mirco Fanelli



VOLUME 16, NUMBER 2

Laboratory Research

Demonstration of Inter- and Intracellular Distribution of Boron and Gadolinium Using Micro-Proton-Induced X-Ray Emission (Micro-PIXE)
K. Endo, T. Yamamoto, Y. Shibata, K. Tsuboi, A. Matsumura, H. Kumada, K. Yamamoto, T. Sakai, T. Sato, M. Oikawa, Y. Ohara, and K. Ishii

Quercetin Induces p53-Independent Apoptosis in Human Prostate Cancer Cells by Modulating Bcl-2-Related Proteins: A Possible Mediation by IGFBP-3
Marati R. Vijayababu, P. Kanagaraj, A. Arunkumar, R. Ilangovan, A. Dharmarajan, and J. Arunakaran

Different Forms of Prolactin Have Opposing Effects on the Expression of Cell Cycle Regulatory Proteins in Differentiated Mammary Epithelial Cells
Wei Wu, Yen-Hao Chen, Eric Ueda, Dunyong Tan, Paolo Bartolini, and Ameae M. Walker

Schedule-Dependent Interactions Between Pemetrexed and Cisplatin in Human Carcinoma Cell Lines In Vitro
Yasuhiko Kano, Miyuki Akutsu, Saburo Tsunoda, Tohru Izumi, Hiroyuki Kobayashi, Koichi Inoue, Kiyoshi Mori, Hirofumi Fujii, Hiroyuki Mano, Tsogbadrakh Odgerel, and Yusuke Furukawa

Synthesis and Antimelanoma Activity of Reversed Amide Analogues of N-Acetyl-4-S-cysteaminylphenol
Kathryn Nicoll, Jane Robertson, Neil Lant, Lloyd R. Kelland, Paul M. Rogers, and David J. Robins



VOLUME 16, NUMBER 1

CONTENTS

Laboratory Research

Inhibition of DMXAA-Induced Tumor Necrosis Factor Production in Murine Splenocyte Cultures by NF-kB Inhibitors
Liang-Chuan S. Wang, See-Tarn Woon, Bruce C. Baguley, and Lai-Ming Ching

ZD6474, an Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinase, Inhibits Growth of Experimental Lung Metastasis and Production of Malignant Pleural Effusions in a Non-Small Cell Lung Cancer Model
Yuka Matsumori, Seiji Yano, Hisatsugu Goto, Emiko Nakataki, Stephen R. Wedge, Anderson J. Ryan, and Saburo Sone

FGF-1 as a Possible Carrier for Targeted Drug Delivery
Ewa Marcinkowska, Katarzyna Superat, and Antoni Wiedlocha

Clinical Research

The Role of Cell-Free DNA Size Distribution in the Management of Prostate Cancer
Jane L. Boddy, Shira Gal, Peter R. Malone, Nadeem Shaida, James S. Wainscoat, and Adrian L. Harris

Are CYP17 Genotypes a Biomarker for Ovarian Cancer in Patients With Cancer History in Their Family?
Hulya Yazici, Hulya Tigli, Zuleyha Kadehci, Seden Kucucuk, Pinar Saip, Halim Issever, Hilmi Ozcelik, and Nejat Dalay

Serum Levels of IGF-I and IGFBP-3 in Patients With Lung Cancer During Chemotherapy
Tomasz Izycki, Elzbieta Chyczewska, Wojciech Naumnik, and Maria Ossolinska

Erratum