Cell Transplantation 21(1-4) Tables of Contents

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VOLUME 21, NUMBER 4

Original Contributions

Impact of Tissue Volume and Purification on Clinical Autologous Islet Transplantation for the Treatment of Chronic Pancreatitis
Shinichi Matsumoto, Morihito Takita, Masayuki Shimoda, Koji Sugimoto, Takeshi Itoh, Daisuke Chujo, Jeffery A. SoRelle, Yoshiko Tamura, Ana M. Rahman, Nicholas Onaca, Bashoo Naziruddin, and Marlon F. Levy

Anti-Inflammatory Properties of Exenatide in Human Pancreatic Islets
S. R. Cechin, I. Pérez-Álvarez, E. Fenjves, R. D. Molano, A. Pileggi, P-O. Berggren, C. Ricordi, and R. L. Pastori

The Effects of Digestion Enzymes on Islet Viability and Cellular Composition
Itzia Iglesias, Luis Valiente, Keh-Dong Shiang, Hirohito Ichii, Fouad Kandeel, and Ismail H. Al-Abdullah

Perfluorocarbon Emulsions Prevent Hypoxia of Pancreatic β-Cells
E. Maillard, M. T. Juszczak, A. Langlois, C. Kleiss, M. C. Sencier, W. Bietiger, M. Sanchez-Dominguez, M. P. Krafft, P. R. V. Johnson, M. Pinget, and S. Sigrist

Normal Hepatocyte Transplantation Delays the Emergence of Chemically Induced Preneoplastic Nodules in Rat Liver
Maria Paola Serra, Silvia Doratiotto, Fabio Marongiu, and Ezio Laconi

Can Magnetic Targeting of Magnetically Labeled Circulating Cells Optimize Intramyocardial Cell Retention?
Aurélie Chaudeurge, Claire Wilhelm, Annabel Chen-Tournoux, Patrick Farahmand, Valérie Bellamy, Gwennhael Autret, Christine Ménager, Albert Hagège, Jerome Larghéro, Florence Gazeau, Olivier Clément, and Philippe Menasché

Combined Mesenchymal Stem Cell Sheets and rhBMP-2-Releasing Calcium Sulfate–rhBMP-2 Scaffolds for Segmental Bone Tissue Engineering
Yiying Qi, Yulu Wang, Weiqi Yan, Hang Li, Zhongli Shi, and Zhijun Pan

Local Transplantation of Granulocyte Colony-Stimulating Factor-Mobilized Human Peripheral Blood Mononuclear Cells for Unhealing Bone Fractures
Tomoaki Fukui, Tomoyuki Matsumoto, Yutaka Mifune, Taro Shoji, Tomoya Kuroda, Yohei Kawakami, Atsuhiko Kawamoto, Masaaki Ii, Shin Kawamata, Masahiro Kurosaka, Takayuki Asahara, and Ryosuke Kuroda

Assessment of Neuroprotective Effects of Human Umbilical Cord Blood Mononuclear Cell Subpopulations In Vitro and In Vivo
Johannes Boltze, Doreen M. Reich, Susann Hau, Klaus G. Reymann, Maria Strassburger, Donald Lobsien, Daniel-Christoph Wagner, Manja Kamprad, and Tobias Stahl

Neural Stem/Progenitor Cells Transplanted to the Hypoglossal Nucleus Integrates With the Host CNS in Adult Rats and Promotes Motor Neuron Survival
Michael Fagerlund, Cynthia Pe´rez Estrada, Nasren Jaff, Mikael Svensson, and Lou Brundin

The Colayer Method as an Efficient Way to Genetically Modify Mesencephalic Progenitor Cells Transplanted Into 6-OHDA Rat Model of Parkinson’s Disease
Andreas Ratzka, Ieva Kalve, Meltem Özer, André Nobre, Maike Wesemann, Julia Jungnickel, Christiane Köster-Patzlaff, Olga Baron, and Claudia Grothe

Fates of Murine Pluripotent Stem Cell-Derived Neural Progenitors Following Transplantation Into Mouse Cochleae
Koji Nishimura, Takayuki Nakagawa, Tatsunori Sakamoto, and Juichi Ito

Abstracts for the 19th Annual Meeting of the American Society for Neural Therapy and Repair

VOLUME 21, NUMBERS 2-3

SPECIAL ISSUE
JOINT JAPAN SOCIETY FOR ORGAN PRESERVATION AND MEDICAL BIOLOGY (JSOPMB)/CELL TRANSPLANT SOCIETY (CTS)

Have Fun and Enjoy it Together at the Joint JSOPMB/CTS Conference
Naoya Kobayashi, Guest Editor-in-Chief, JSOPMB/CTS Issue

Review

Regenerative Cells for Transplantation in Hepatic Failure
Tetsuya Ishikawa, Agnieszka Banas, Takumi Teratani, Hideki Iwaguro, and Takahiro Ochiya

Original Contributions

Direct Oxygen Supply With Polydimethylsiloxane (PDMS) Membranes Induces a Spontaneous Organization of Thick Heterogeneous Liver Tissues From Rat Fetal Liver Cells In Vitro
Morgan Hamon, Sanshiro Hanada, Teruo Fujii, and Yasuyuki Sakai

Cell Shape Regulation Based on Hepatocyte Sheet Engineering Technologies
Soichi Takagi, Maki Ohno, Kazuo Ohashi, Rie Utoh, Kohei Tatsumi, and Teruo Okano

Evaluation of a Hybrid Artificial Liver Module Based on a Spheroid Culture System of Embryonic Stem Cell-Derived Hepatic Cells
Hiroshi Mizumoto, Shunsuke Hayashi, Kinya Matsumoto, Kaoru Ikeda, Tomoaki Kusumi, Masakazu Inamori, Kohji Nakazawa, Hiroyuki Ijima, Kazumori Funatsu, and Toshihisa Kajiwara

Liver Tissue Engineering Utilizing Hepatocytes Propagated in Mouse Livers In Vivo
Kazuo Ohashi, Kohei Tatsumi, Chise Tateno, Miho Kataoka, Rie Utoh, Katsutoshi Yoshizato, and Teruo Okano

Human Hepatocyte Propagation System in the Mouse Livers: Functional Maintenance of the Production of Coagulation and Anticoagulation Factors
Kohei Tatsumi, Kazuo Ohashi, Chise Tateno, Katsutoshi Yoshizato, Akira Yoshioka, Midori Shima, and Teruo Okano

Repopulation of Human Origin Hepatocyte Progenitor-Like Cell Line, THLE-5b, in the SCID Mouse Liver Under p21-Mediated Cell Growth-Arresting Conditions
Shin Enosawa, Taisuke Yamazaki, Hitoshi Kohsaka, and Takayoshi Tokiwa

Matrix Metalloproteinase-9 Contributes to the Mobilization of Bone Marrow Cells in the Injured Liver
Kengo Kawai, Feng Xue, Terumi Takahara, Hiroshi Kudo, Yutaka Yata, Wei Zhang, and Toshiro Sugiyama

Improvement of Porcine Islet Isolation by Inhibition of Trypsin Activity During Pancreas Preservation and Digestion Using α1-Antitrypsin
Masayuki Shimoda, Hirofumi Noguchi, Yasutaka Fujita, Morihito Takita, Tetsuya Ikemoto, Daisuke Chujo, Bashoo Naziruddin, Marlon F. Levy, Naoya Kobayashi, Paul A. Grayburn, and Shinichi Matsumoto

A Model to Evaluate Toxic Factors Influencing Islets During Collagenase Digestion: The Role of Serine Protease Inhibitor in the Protection of Islets
Manabu Tsukada, Takuro Saito, Kazuya Ise, Akira Kenjo, Takashi Kimura, Yoshihiro Satoh, Takaharu Saito, Takayuki Anazawa, Ikuro Oshibe, Shigeya Suzuki, Yasuhiro Hashimoto, and Mitsukazu Gotoh

Adenine Nucleotide Levels in a Closed Enzymatic Digestion System for Porcine Islet Isolation
Ikuro Oshibe, Takuro Saito, Yoshihiro Sato, Takaharu Saito, Manabu Tsukada, Kazuya Ise, Akira Kenjo, Takashi Kimura, Takayuki Anazawa, Shigeya Suzuki, Yasuhiro Hashimoto, and Mitusukazu Gotoh

Evaluation of Osmolality of Density Gradient for Human Islet Purification
Hirofumi Noguchi, Bashoo Naziruddin, Masayuki Shimoda, Yasutaka Fujita, Daisuke Chujo, Morihito Takita, Han Peng, Koji Sugimoto, Takeshi Itoh, Naoya Kobayashi, Nicholas Onaca, Marlon F. Levy, and Shinichi Matsumoto

Islet Purification Method Using Large Bottles Effectively Achieves High Islet Yield From Pig Pancreas
Masayuki Shimoda, Hirofumi Noguchi, Yasutaka Fujita, Morihito Takita, Tetsuya Ikemoto, Daisuke Chujo, Bashoo Naziruddin, Marlon F. Levy, Naoya Kobayashi, Paul A. Grayburn, and Shinichi Matsumoto

Comparison of Ulinastatin, Gabexate Mesilate, and Nafamostat Mesilate in Preservation Solution for Islet Isolation
Hirofumi Noguchi, Bashoo Naziruddin, Andrew Jackson, Masayuki Shimoda, Yasutaka Fujita, Daisuke Chujo, Morihito Takita, Han Peng, Koji Sugimoto, Takeshi Itoh, Naoya Kobayashi, Michiko Ueda, Teru Okitsu, Yasuhiro Iwanaga, Hideo Nagata, Xiaoling Liu, Hiroki Kamiya, Nicholas Onaca, Marlon F. Levy, and Shinichi Matsumoto

Fresh Islets Are More Effective for Islet Transplantation Than Cultured Islets
Hirofumi Noguchi, Bashoo Naziruddin, Andrew Jackson, Masayuki Shimoda, Tetsuya Ikemoto, Yasutaka Fujita, Daisuke Chujo, Morihito Takita, Han Peng, Koji Sugimoto, Takeshi Itoh, Naoya Kobayashi, Nicholas Onaca, Marlon F. Levy, and Shinichi Matsumoto

Immunoisolation Effect of Polyvinyl Alcohol (PVA) Macroencapsulated Islets in Type 1 Diabetes Therapy
Zhi Qi, Chizuru Yamamoto, Naomi Imori, Ayano Kinukawa, Kai-chiang Yang, Goichi Yanai, Etsuko Ikenoue, Yanna Shen, Yasumasa Shirouzu, Akihito Hiura, Kazutomo Inoue, and Shoichiro Sumi

Mizoribine as Sole Immunosuppressive Agent in Islet Xenotransplantation Models: A Candidate Immunosuppressant Causing no Adverse Effects on Islets
Michitoshi Yamashita, Takuro Saito, Kazuya Ise, Show Ishii, Yoshihiro Satoh, Takaharu Saito, Ikuro Oshibe, Hirofumi Shimizu, Akira Kenjo, Takashi Kimura, and Mitsukazu Gotoh

Adverse Events in Clinical Islet Transplantation: One Institutional Experience
Morihito Takita, Shinichi Matsumoto, Hirofumi Noguchi, Masayuki Shimoda, Tetsuya Ikemoto, Daisuke Chujo, Yoshiko Tamura, Greg S. Olsen, Bashoo Naziruddin, Kerri Purcell, Nicholas Onaca, and Marlon F. Levy

Improved Pancreatic Islet Isolation Outcome in Autologous Transplantation for Chronic Pancreatitis
Bashoo Naziruddin, Shinichi Matsumoto, Hirofumi Noguchi, Morihito Takita, Masayuki Shimoda, Yasutaka Fujita, Daisuke Chujo, Chad Tate, Nicholas Onaca, Jeffrey Lamont, Naoya Kobayashi, and Marlon F. Levy

Results of Islet Isolation and Their Relationship to the Clinical Outcome of Kidney Transplantation in Cases Where Both Grafts Are Harvested From the Same Non-Heart-Beating Donor
Michihiro Maruyama, Takashi Kenmochi, Kenichi Saigo, Akutsu Naotake, Chikara Iwashita, Kazunori Otsuki, and Taihei Ito

Comparative Study of the Cellular Pharmacodynamics of Tacrolimus in Renal Transplant Recipients Treated With and Without Basiliximab
Kentaro Sugiyama, Kazuya Isogai, Satoshi Horisawa, Akira Toyama, Hiroshi Satoh, Kazuhide Saito, Yuki Nakagawa, Masayuki Tasaki, Kota Takahashi, and Toshihiko Hirano

Carbamylated Erythropoietin Ameliorates Cyclosporine Nephropathy Without Stimulating Erythropoiesis
Toyofumi Abe, Yoshitaka Isaka, Ryoichi Imamura, Yoichi Kakuta, Masayoshi Okumi, Koji Yazawa, Naotsugu Ichimaru, Hidetoshi Tsuda, Norio Nonomura, Shiro Takahara, and Akihiko Okuyama

Bone Marrow-Derived Conventional, But Not Cloned, Mesenchymal Stem Cells Suppress Lymphocyte Proliferation and Prevent Graft-Versus-Host Disease in Rats
Yusuke Kitazawa, Xiao-Kang Li, Lin Xie, Ping Zhu, Hiromitsu Kimura, and Shiro Takahara

Transplantation of Osteogenically Differentiated Mouse iPS Cells for Bone Repair
Takahiro Hayashi, Haruo Misawa, Hiroyuki Nakahara, Hirofumi Noguchi, Aki Yoshida, Naoya Kobayashi, Masato Tanaka, and Toshifumi Ozaki

Tissue Augmentation by White Blood Cell-Containing Platelet-Rich Plasma
Takeshi Kawazoe and Hak Hee Kim

Preservation by Desiccation of Isolated Rat Hearts for 48 Hours Using Carbon Monoxide (PCO = 4,000 hPa) and Oxygen (PO2 = 3,000 hPa)
Naoyuki Hatayama, Munekazu Naito, Shuichi Hirai, Yu Yoshida, Tomohiro Kojima, Kunihiro Seki, Xiao-Kang Li, and Masahiro Itoh

Cryopreservation of Human Adipose Tissue-Derived Stem/Progenitor Cells Using the Silk Protein Sericin
Yoshitaka Miyamoto, Koichi Oishi, Hiroshi Yukawa, Hirofumi Noguchi, Masahiro Sasaki, Hisashi Iwata, and Shuji Hayashi

Erratum

VOLUME 21, NUMBER 1

Review

Improving the Techniques for Human Hepatocyte Transplantation: Report From a Consensus Meeting in London
Juliana Puppi, Stephen C. Strom, Robin D. Hughes, Sanjay Bansal, Jose V. Castell, Ibrahim Dagher, Ewa C. S. Ellis, Greg Nowak, Bo-Goran Ericzon, Ira J. Fox, M. José Gómez-Lechón, Chandan Guha, Sanjeev Gupta, Ragai R. Mitry, Kazuo Ohashi, Michael Ott, Lola M. Reid, Jayanta Roy-Chowdhury, Etienne Sokal, Anne Weber, and Anil Dhawan

Original Contributions

Growth Ability and Repopulation Efficiency of Transplanted Hepatic Stem Cells, Progenitor Cells, and Mature Hepatocytes in Retrorsine-Treated Rat Livers
Norihisa Ichinohe, Junko Kon, Kazunori Sasaki, Yukio Nakamura, Hidekazu Ooe, Naoki Tanimizu, and Toshihiro Mitaka

Improvement of the Cold Storage of Isolated Human Hepatocytes
Gesine Pless, Igor M. Sauer, and Ursula Rauen

Evaluation of Viable β-Cell Mass Is Useful for Selecting Collagenase for Human Islet Isolation: Comparison of Collagenase NB1 and Liberase HI
R. Misawa, C. Ricordi, A. Miki, S. Barker, R. D. Molano, A. Khan, S. Miyagawa, L. Inverardi, R. Alejandro, A. Pileggi, and H. Ichii

Expression of Pro- and Antiapoptotic Molecules of the Bcl-2 Family in Human Islets Postisolation
Peter D. Campbell, Anita Weinberg, Jonathan Chee, Lina Mariana, Rochelle Ayala, Wayne J. Hawthorne, Philip J. O’Connell, Thomas Loudovaris, Mark J. Cowley, Thomas W. Kay, Shane T. Grey, and Helen E. Thomas

Tissue Factor Knockdown in Porcine Islets: An Effective Approach to Suppressing the Instant Blood-Mediated Inflammatory Reaction
Xiaoqian Ma, Bin Ye, Feng Gao, Qi Liang, Qiong Dong, Yin Liu, Pengfei Rong, Wei Wang, and Shounan Yi

In Vitro Generation of Pancreatic Endocrine Cells From Human Adult Fibroblast-Like Limbal Stem Cells
Angela Criscimanna, Giovanni Zito, Annalisa Taddeo, Pierina Richiusa, Maria Pitrone, Daniele Morreale, Gaetano Lodato, Giuseppe Pizzolanti, Roberto Citarrella, Aldo Galluzzo, and Carla Giordano

Secretory Unit of Islet Transplant Objects (SUITO) Index Can Predict Severity of Hypoglycemic Episodes in Clinical Islet Cell Transplantation
Morihito Takita, Shinichi Matsumoto, Huanying Qin, Hirofumi Noguchi, Masayuki Shimoda, Daisuke Chujo, Takeshi Itoh, Koji Sugimoto, Nicholas Onaca, Bashoo Naziruddin, and Marlon F. Levy

B7-H4 Induces Donor-Specific Tolerance in Mouse Islet Allografts
Xiaojie Wang, Jianqiang Hao, Daniel L. Metzger, Alice Mui, Ziliang Ao, C. Bruce Verchere, Lieping Chen, Dawei Ou, and Garth L. Warnock

Quantitative In Situ Analysis of FoxP3+ T Regulatory Cells on Transplant Tissue Using Laser Scanning Cytometry
Hidenori Takahashi, Phillip Ruiz, Camillo Ricordi, Victor Delacruz, Atsushi Miki, Atsuyoshi Mita, Ryosuke Misawa, Scott Barker, George W. Burke, Andreas G. Tzakis, and Hirohito Ichii

Fibrin Gel Improves the Survival of Transplanted Myoblasts
Catherine Gerard, Marie Anne Forest, Genevieve Beauregard, Daniel Skuk, and Jacques P. Tremblay

Losartan Enhances the Success of Myoblast Transplantation
Raouia Fakhfakh, Yann Lamarre, Daniel Skuk, and Jacques P. Tremblay

Myogenic Properties of Human Mesenchymal Stem Cells Derived From Three Different Sources
Anabel S. de la Garza-Rodea, Ietje van der Velde-van Dijke, Hester Boersma, Manuel A. F. V. Gonçalves, Dirk W. van Bekkum, Antoine A. F. de Vries, and Shoshan Knaän-Shanzer

Autologous Lung-Derived Mesenchymal Stem Cell Transplantation in Experimental Emphysema
Edward P. Ingenito, Larry Tsai, Shankar Murthy, Shivraj Tyagi, Melissa Mazan, and Andrew Hoffman

Cationic Gd-DTPA Liposomes for Highly Efficient Labeling of Mesenchymal Stem Cells and Cell Tracking With MRI
Jamal Guenoun, Gerben A. Koning, Gabriela Doeswijk, Lizanne Bosman, Piotr A. Wielopolski, Gabriel P. Krestin, and Monique R. Bernsen

Banking Human Umbilical Cord-Derived Mesenchymal Stromal Cells for Clinical Use
Wei Gong, Zhibo Han, Hui Zhao, Youwei Wang, Jiming Wang, Jian Zhong, Bin Wang, Shanshan Wang, Yongjuan Wang, Lingyun Sun, and Zhongchao Han

Derivation of High-Purity Definitive Endoderm From Human Parthenogenetic Stem Cells Using an In Vitro Analog of the Primitive Streak
Nikolay Turovets, Jeffrey Fair, Richard West, Alina Ostrowska, Ruslan Semechkin, Jeffrey Janus, Li Cui, Vladimir Agapov, Irina Turovets, Andrey Semechkin, Marie Csete, and Larissa Agapova

Human Adipose Tissue as a Source of Cells With Angiogenic Potential
Krisztina Szöke, Karen Johanne Beckstrøm, and Jan E. Brinchmann

Transcriptional Profiling of the Hematopoietic Support of Interleukin-Stimulated Human Umbilical Vein Endothelial Cells (HUVECs)
Gürkan Bal, Julian Kamhieh-Milz, Matthias Futschik, Thomas Häupl, Abdulgabar Salama, and Anja Moldenhauer

Bypassing the Patient: Comparison of Biocompatible Models for the Future of Vascular Tissue Engineering
L. Khait and R. K. Birla

Seeding of Endothelial Cells on the Luminal Surface of a Sheet Model of Cold-Stored (at 4°C) Sheep Carotid Arteries
Arthur Smardencas and Helena C. Parkington

In Situ Cardiomyogenic Differentiation of Implanted Bone Marrow Mononuclear Cells by Local Delivery of Transforming Growth Factor-β1
Hee Seok Yang, Suk Ho Bhang, Il-Kwon Kim, Tae-Jin Lee, Jin-Muk Kang, Dae-Hee Lee, Soo-Hong Lee, Ki-Chul Hwang, and Byung-Soo Kim

Docosahexaenoic Acid Promotes Dopaminergic Differentiation in Induced Pluripotent Stem Cells and Inhibits Teratoma Formation in Rats With Parkinson-Like Pathology
Yuh-Lih Chang, Shih-Jen Chen, Chung-Lan Kao, Shih-Chieh Hung, Dah-Ching Ding, Cheng-Chia Yu, Yi-Jen Chen, Hung-Hai Ku, Chin-Po Lin, Kun-Hsiung Lee, Yu-Chih Chen, Jhi-Joung Wang, Chuan-Chih Hsu, Liang-Kung Chen, Hsin-Yang Li, and Shih-Hwa Chiou

Targeted Intra-arterial Transplantation of Stem Cells to the Injured CNS Is More Effective Than Intravenous Administration: Engraftment Is Dependent on Cell Type and Adhesion Molecule Expression
Johan Lundberg, Erik Södersten, Erik Sundström, Katarina Le Blanc, Tommy Andersson, Ola Hermanson, and Staffan Holmin

Suppression of Etk/Bmx Protects Against Ischemic Brain Injury
Kai-Yun Chen, Chung-Che Wu, Cheng-Fu Chang, Yuan-Hao Chen, Wen-Ta Chiu, Ya-Hsin Lou, Yen-Hua Chen, Hsiu-Ming Shih, and Yung-Hsiao Chiang

Stem Cells Decreased Neuronal Cell Death After Hypoxic Stress in Primary Fetal Rat Neurons In Vitro
Tetsuro Sakai and Yan Xu

Brief Communications

Human Neural Stem Cells Overexpressing Choline Acetyltransferase Restore Cognitive Function of Kainic Acid-Induced Learning and Memory Deficit Animals
Dongsun Park, Seong Soo Joo, Tae Kyun Kim, Sun Hee Lee, Hyomin Kang, Hong Jun Lee, Inja Lim, Akinori Matsuo, Ikuo Tooyama, Yun-Bae Kim, and Seung U. Kim

GMP-Compliant Culture of Human Hair Follicle Cells for Encapsulation and Transplantation
Mario Marazzi, Francesca Crovato, Massimo Bucco, Maria Chiara Sironi, Marta Cecilia Tosca, Barbara Antonioli, Theodora Chlapanidas, Giulia Lucconi, Vincenzo Rapisarda, Alessandro Scalise, Daniele Vigo, Massimo Faustini, and Maria Luisa Torre

Cell Medicine, Part B of Cell Transplantation Volume 2, Number 3 Abstracts

Resident Endothelial Progenitor Cells From Human Placenta Have Greater Vasculogenic Potential Than Circulating Endothelial Progenitor Cells From Umbilical Cord Blood
Brian M. Rapp, M. Reza Saadatzedeh, Richard H. Ofstein, Janak R. Bhavsar, Zachary S. Tempel, Oscar Moreno, Peter Morone, Dana A. Booth, Dmitry O. Traktuev, Michael C. Dalsing, David A. Ingram, Mervin C. Yoder, Keith L. March, and Michael P. Murphy

Validation of Islet Transport From a Geographically Distant Isolation Center Enabling Equitable Access and National Health Service Funding of a Clinical Islet Transplant Program for England
Ali Aldibbiat, Guo Cai Huang, Min Zhao, Graham N. Holliman, Linda Ferguson, Stephen Hughes, Ken Brigham, Julie Wardle, Rob Williams, Anne Dickinson, Steven A. White, Paul R. V. Johnson, Derek Manas, Stephanie A. Amiel, and James A. M. Shaw

Hypothermic Perfusion Preservation of Pancreas for Islet Grafts: Validation Using a Split Lobe Porcine Model
B. P. Weegman, M. J. Taylor, S. C. Baicu, W. E. Scott, III, K. R. Mueller, J. D. Kitzmann, M. D. Rizzari, and K. K. Papas